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Showing 1–4 of 4 results
Advanced filters: Author: Florent Peglion Clear advanced filters

  • Pten is a tumour suppressor gene that is associated with highly invasive cancers such as glioblastoma. Here the authors show that PTEN loss results in increased migratory behaviour, which can be countered by targeting AMPK activity.

    • Florent Peglion
    • Lavinia Capuana
    • Sandrine Etienne-Manneville
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • The proteins tasked with establishing polarity in a cell undergo reaction–diffusion dynamics that are shown here to impose a cell-size threshold on polarization. The limit may facilitate switching between symmetric and asymmetric modes of division.

    • Lars Hubatsch
    • Florent Peglion
    • Nathan W. Goehring
    Research
    Nature Physics
    Volume: 15, P: 1078-1085

  • Etienne-Manneville and colleagues demonstrate that the adherens junctions of adjacent migrating cultured cells exhibit retrograde flow along the lateral cell sides. They show that the rearward treadmilling of junctions is followed by N-cadherin endocytosis at the cell rear and anterograde trafficking to support formation of new junctional complexes at the cell front.

    • Florent Peglion
    • Flora Llense
    • Sandrine Etienne-Manneville
    Research
    Nature Cell Biology
    Volume: 16, P: 639-651

  • Substrate-rigidity-dependent microtubule acetylation is now shown to be triggered by mechanosensing at focal adhesions, and in turn controls the mechanosensitivity of Yes-associated protein (YAP) translocation, focal adhesion distribution, actomyosin contractility and cell migration.

    • Shailaja Seetharaman
    • Benoit Vianay
    • Sandrine Etienne-Manneville
    Research
    Nature Materials
    Volume: 21, P: 366-377