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Showing 1–7 of 7 results

Advanced filters: Author: Florian Gaertner Clear advanced filters

Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis

Plasmacytoid dendritic cells monitor the bone marrow for apoptotic megakaryocytes (MKs) and deliver IFNα to the MK niche, triggering local on-demand proliferation and maturation of MK progenitors.

Florian Gaertner
Hellen Ishikawa-Ankerhold
Steffen Massberg
ResearchOpen Access10 Jul 2024
Nature

Volume: 631, P: 645-653
Vascular surveillance by haptotactic blood platelets in inflammation and infection

Breakdown of vascular barriers is a major complication of inflammatory diseases. However, the mechanisms underlying platelet recruitment to inflammatory micro-environments remains unclear. Here, the authors identify haptotaxis as a key effector function of immune-responsive platelets

Leo Nicolai
Karin Schiefelbein
Florian Gaertner
ResearchOpen Access13 Nov 2020
Nature Communications

Volume: 11, P: 1-16
Author Correction: Vascular surveillance by haptotactic blood platelets in inflammation and infection

Leo Nicolai
Karin Schiefelbein
Florian Gaertner
Amendments and CorrectionsOpen Access08 Aug 2022
Nature Communications

Volume: 13, P: 1-4
Cellular locomotion using environmental topography

Within three-dimensional environments, leukocytes can migrate even in the complete absence of adhesive forces using the topographical features of the substrate to propel themselves.

Anne Reversat
Florian Gaertner
Michael Sixt
Research13 May 2020
Nature

Volume: 582, P: 582-585
Migrating immune cells globally coordinate protrusive forces

Sixt and colleagues show that, in environments where even the largest pores preclude free passage, leukocytes position their nucleus behind the centrosome and assemble a central F-actin pool that pushes outward to transiently dilate a path for the nucleus.

Patricia Reis-Rodrigues
Mario J. Avellaneda
Michael Sixt
ResearchOpen Access15 Jul 2025
Nature Immunology

Volume: 26, P: 1258-1266
Patrolling the vascular borders: platelets in immunity to infection and cancer

Platelets are best known for their roles in haemostasis, but they also contribute to host immunity. In this Review, Gaertner and Massberg consider how platelets ‘patrol the vascular highway’ to shape immune responses during infection and cancer.

Florian Gaertner
Steffen Massberg
Reviews13 Aug 2019
Nature Reviews Immunology

Volume: 19, P: 747-760
Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells

Sixt, Stein and colleagues show that during T cell migration within lymphatic organs, the chemokine receptor CCR7 quantitatively controls the speed of a continuous actin flow, which is coupled to the environment by the integrin LFA-1.

Miroslav Hons
Aglaja Kopf
Michael Sixt
Research18 May 2018
Nature Immunology

Volume: 19, P: 606-616