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Showing 1–2 of 2 results
Advanced filters: Author: Florian Leidner Clear advanced filters

  • Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule substrates, beyond proteins. This discovery may be harnessed to develop specific tool substrates or inhibitors of HECT-type ligases.

    • Barbara Orth
    • Pavel Pohl
    • Sonja Lorenz
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • ER membranes tune protein degradation to lipid composition. Using reconstitution approaches, the authors show that the ubiquitin conjugating enzyme UBE2J2 senses lipid packing, modulating its own and partner enzyme activities; together, they integrate lipid saturation and cholesterol signals.

    • Aikaterini Vrentzou
    • Florian Leidner
    • Alexander Stein
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20