Differences in genomic GC content skew species abundances in microbial communities. Here, the authors develop GuaCAMOLE, a computational method that quantifies this GC bias from metagenomic sequencing data and corrects abundances accordingly, showing its application increases abundances of some pathogenic bacteria up to twofold in human gut microbiomes.
- Laurenz Holcik
- Arndt von Haeseler
- Florian G. Pflug
