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Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications

Cognitive dysfunction is an important comorbidity of diabetes mellitus. In this Review, Geert Jan Biessels and Florin Despa discuss the different manifestations of diabetes-mellitus-associated cognitive dysfunction. They also review the role of experimental models in improving our understanding of the pathophysiological mechanisms.

Geert Jan Biessels
Florin Despa
Reviews18 Jul 2018
Nature Reviews Endocrinology

Volume: 14, P: 591-604
Gestational diabetes triggers postpartum cardiac hypertrophy via activation of calcineurin/NFAT signaling

Nirmal Verma
Sarah Srodulski
Sanda Despa
ResearchOpen Access22 Oct 2021
Scientific Reports

Volume: 11, P: 1-12
Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas

Converging data from humans and laboratory animals suggest that altering bloodborne amylin could potentially reduce cerebrovascular amylin deposits and Aβ pathology in Alzheimer’s disease brains.

Nirmal Verma
Gopal Viswanathan Velmurugan
Florin Despa
ResearchOpen Access03 Jan 2023
Communications Biology

Volume: 6, P: 1-16
Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart

Anne Van Steenbergen
Magali Balteau
Christophe Beauloye
ResearchOpen Access27 Jan 2017
Scientific Reports

Volume: 7, P: 1-14
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation

CaMKII is known to be pathologically activated in heart failure and arrhythmias; here it is shown that glucose-induced CaMKII activation via O-linked glycosylation might contribute to cardiac pathology in diabetes.

Jeffrey R. Erickson
Laetitia Pereira
Donald M. Bers
Research29 Sept 2013
Nature

Volume: 502, P: 372-376

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Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications

Gestational diabetes triggers postpartum cardiac hypertrophy via activation of calcineurin/NFAT signaling

Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas

Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart

Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation

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