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Nature Immunology (1)

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Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation

NLRP6 is highly expressed in the gut; however, persistent NLRP6 activation can lead to excessive IL-18 production and intestinal bowel disease. Venuprasad and colleagues identify the K63-linked ubiquitin deubiquitinase Cyld as a negative regulator of NLRP6.

Sandip Mukherjee
Ritesh Kumar
K. Venuprasad
Research18 May 2020
Nature Immunology

Volume: 21, P: 626-635

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Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation

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