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Showing 1–4 of 4 results
Advanced filters: Author: Françoise Coussen Clear advanced filters

  • Auxiliary AMPA receptor subunits can affect gating and surface mobility. Here the authors show that Shisa6 traps AMPA receptors at postsynaptic sites via PSD-95, and keeps them in an activated state in the presence of glutamate, preventing full desensitization and consequently synaptic depression.

    • Remco V. Klaassen
    • Jasper Stroeder
    • August B. Smit
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • The process of SUMOylation affects various cellular events by modifying the proteins involved. In neurons, it controls receptor numbers on the cell surface, thereby regulating neuronal communication.

    • Françoise Coussen
    • Daniel Choquet
    News & Views
    Nature
    Volume: 447, P: 271-272

  • Cognitive decline in Huntington’s disease (HD) may be due to impaired hippocampal synaptic plasticity. In this study the authors show that AMPA receptor surface diffusion, a key player in synaptic plasticity, is deregulated in multiple HD mouse models as a result of impaired BDNF signalling that underlies the memory deficits, and can be pharmacologically rescued.

    • Hongyu Zhang
    • Chunlei Zhang
    • Daniel Choquet
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Glutamate-induced kainate receptor activation can inhibit or facilitate inhibitory synaptic transmission. This study demonstrates that it is the concerted activity of presynaptic CB1 receptors and kainate receptors that together mediate short-term depression of inhibitory synaptic transmission.

    • Joana Lourenço
    • Astrid Cannich
    • Giovanni Marsicano
    Research
    Nature Neuroscience
    Volume: 13, P: 197-204