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Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

Halbrook et al. report two metabolic subgroups of pancreatic ductal adenocarcinoma cells defined by differential integrated stress response and asparagine production that permit symbiosis and phenformin resistance.

Christopher J. Halbrook
Galloway Thurston
Costas A. Lyssiotis
ResearchOpen Access21 Nov 2022
Nature Cancer

Volume: 3, P: 1386-1403

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Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

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