Nature Search

Truncation of Kir6.2 produces ATP-sensitive K⁺ channels in the absence of the sulphonylurea receptor

Stephen J. Tucker
Fiona M. Gribble
Frances M. Ashcroft
Research08 May 1997
Nature

Volume: 387, P: 179-183
Modulation of dihydropyridine-sensitive Ca²⁺ channels by glucose metabolism in mouse pancreatic β -cells

Paul A. Smith
Patrik Rorsman
Frances M. Ashcroft
Research30 Nov 1989
Nature

Volume: 342, P: 550-553
Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells

Frances M. Ashcroft
Donna E. Harrison
Stephen J. H. Ashcroft
Research29 Nov 1984
Nature

Volume: 312, P: 446-448
Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels

Carlna Ämmälä
Andrew Moorhouse
Frances M. Ashcroft
Research08 Feb 1996
Nature

Volume: 379, P: 545-548
Gating of a muscle K⁺ channel and its dependence on the permeating ion species

P. R. Stanfield
Frances M. Ashcroft
T. D. Plant
Research05 Feb 1981
Nature

Volume: 289, P: 509-511
Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells

Carina Ämmälä
Frances M. Ashcroft
Patrik Rorsman
Research27 May 1993
Nature

Volume: 363, P: 356-358
Sweet news for hypoglycemic babies

Pancreatic β-cells from PHHI patients lack functional K_ATP channels (pages 1344–1347).

Frances M. Ashcroft
News & Views01 Dec 1996
Nature Medicine

Volume: 2, P: 1301-1302
T-system optical signals associated with inward rectification in skeletal muscle

Judith A. Heiny
Frances M. Ashcroft
Julio Vergara
Research13 Jan 1983
Nature

Volume: 301, P: 164-166
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

Pancreatic beta-cell glucose metabolism is coupled to insulin secretion. Here the authors set out to characterize changes in beta-cell metabolism in hyperglycemia which may contribute to insufficient insulin secretion in type 2 diabetes and, using a multi-omics approach, find that mitochondrial metabolism is perturbed.

Elizabeth Haythorne
Maria Rohm
Frances M. Ashcroft
ResearchOpen Access06 Jun 2019
Nature Communications

Volume: 10, P: 1-17
ATP-sensitive K⁺ channels in the hypothalamus are essential for the maintenance of glucose homeostasis

Takashi Miki
Birgit Liss
Susumu Seino
Research01 May 2001
Nature Neuroscience

Volume: 4, P: 507-512
FTO influences adipogenesis by regulating mitotic clonal expansion

Mutations in the FTO gene have been linked to obesity. Here, Merkestein et al. provide in vitro and in vivo evidence that FTOdirectly regulates adipogenesis in mice at the stage of mitotic clonal expansion, likely by modulating the expression of the transcription factor RUNX1T1.

Myrte Merkestein
Samantha Laber
Roger D. Cox
ResearchOpen Access17 Apr 2015
Nature Communications

Volume: 6, P: 1-9
Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells

Chronic hyperglycemia impairs insulin secretion from pancreatic beta cells in diabetes. Here, the authors reveal that a glucose metabolite is responsible and show lowering glucose metabolism during hyperglycemia prevents loss of beta-cell function.

Elizabeth Haythorne
Matthew Lloyd
Frances M. Ashcroft
ResearchOpen Access14 Nov 2022
Nature Communications

Volume: 13, P: 1-19
Sulfonylurea improves CNS function in a case of intermediate DEND syndrome caused by a mutation in KCNJ11

In this Case Study, the authors describe how sulfonylurea therapy not only restored glucose homeostasis, but also alleviated some of the neurological symptoms in a patient with intermediate DEND syndrome. Single-photon emission CT provided evidence of increased CNS blood flow and function that correlated with mental and motor improvements.

Wojciech Mlynarski
Andrei I Tarasov
Frances M Ashcroft
Reviews01 Nov 2007
Nature Clinical Practice Neurology

Volume: 3, P: 640-645
K_ATP channels and islet hormone secretion: new insights and controversies

K_ATPchannels have a key role in the regulation of blood glucose homeostasis. This Review outlines their role in the regulation of insulin and glucagon release, which decrease and increase blood glucose levels respectively, under both physiological conditions and in disease states such as diabetes mellitus and hyperinsulinism.

Frances M. Ashcroft
Patrik Rorsman
Reviews17 Sept 2013
Nature Reviews Endocrinology

Volume: 9, P: 660-669
Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Diabetes is characterized by prolonged hyperglycaemia and tissue damage in pancreatic islets. Here, Brereton et al. show that chronic high glucose levels lead to glycogen accumulation in β-cells, associated with reduced autophagy, impaired metabolism, insulin granule depletion and apoptosis.

Melissa F. Brereton
Maria Rohm
Frances M. Ashcroft
ResearchOpen Access24 Nov 2016
Nature Communications

Volume: 7, P: 1-15
Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

In patients with diabetes, insulin release from pancreatic β-cells is reduced due to altered islet structure and function. Here, Brereton et al. show that elevated blood glucose underlies these changes and is sufficient to reversibly alter β-cell identity in a mouse model of β-cell dysfunction.

Melissa F. Brereton
Michaela Iberl
Frances M. Ashcroft
ResearchOpen Access22 Aug 2014
Nature Communications

Volume: 5, P: 1-11
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Impaired glucagon secretion in patients with diabetes causes hypoglycemia. Here the authors show that therapeutic concentrations of insulin inhibit alpha-cell glucagon secretion by stimulating delta-cell insulin receptor and the release of somatostatin. Blocking somatostatin secretion or action ameliorates this effect.

Elisa Vergari
Jakob G. Knudsen
Patrik Rorsman
ResearchOpen Access11 Jan 2019
Nature Communications

Volume: 10, P: 1-11
Overexpression of Fto leads to increased food intake and results in obesity

Genetic variants at the FTO gene are associated with obesity in humans. Now, Roger Cox and colleagues analyze mice globally overexpressing Fto and show that increased Fto expression leads to obesity in mice.

Chris Church
Lee Moir
Roger D Cox
Research14 Nov 2010
Nature Genetics

Volume: 42, P: 1086-1092
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

Genetic and testing data from England show that the SARS-CoV-2 variant of concern B.1.1.7 has a transmission advantage over other lineages.

Erik Volz
Swapnil Mishra
Neil M. Ferguson
Research25 Mar 2021
Nature

Volume: 593, P: 266-269
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Post-international travel quarantine has been widely implemented to mitigate SARS-CoV-2 transmission, but the impacts of such policies are unclear. Here, the authors used linked genomic and contact tracing data to assess the impacts of a 14-day quarantine on return to England in summer 2020.

Dinesh Aggarwal
Andrew J. Page
Ewan M. Harrison
ResearchOpen Access23 Feb 2022
Nature Communications

Volume: 13, P: 1-13
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes

Impaired somatostatin secretion owing to loss of β- to δ-cell electrical coupling underlies defective counter-regulatory glucagon secretion in type-1 diabetes.

Thomas G. Hill
Rui Gao
Quan Zhang
ResearchOpen Access23 Sept 2024
Nature Metabolism

Volume: 6, P: 2070-2081
From molecule to malady

Frances M. Ashcroft
Reviews22 Mar 2006
Nature

Volume: 440, P: 440-447
New insights into K_ATP channel gene mutations and neonatal diabetes mellitus

Gain-of-function mutations in the genes encoding ATP-sensitive potassium channel (K_ATP channel) subunits cause neonatal diabetes mellitus. This Review discusses the mechanism of action of mutations that lead to neonatal diabetes mellitus and briefly reviews work on the management of this disease.

Tanadet Pipatpolkai
Samuel Usher
Frances M. Ashcroft
Reviews06 May 2020
Nature Reviews Endocrinology

Volume: 16, P: 378-393
Evaluating inositol phospholipid interactions with inward rectifier potassium channels and characterising their role in disease

Protein-lipid interactions can mediate the function of membrane proteins. Here coarse-grained molecular dynamics free energy perturbation simulations yield binding free energies for phosphoinositide lipids to hKir channels and mutants, in agreement with electrophysiological measurements.

Tanadet Pipatpolkai
Robin A. Corey
Phillip J. Stansfeld
ResearchOpen Access30 Oct 2020
Communications Chemistry

Volume: 3, P: 1-10
R-type Ca²⁺-channel-evoked CICR regulates glucose-induced somatostatin secretion

Quan Zhang
Martin Bengtsson
Patrik Rorsman
Research18 Mar 2007
Nature Cell Biology

Volume: 9, P: 453-460
Delayed diagnosis resulting in increased disease burden in multiple myeloma: the legacy of the COVID-19 pandemic

Jonathan Carmichael
Frances Seymour
Gordon Cook
ResearchOpen Access15 Mar 2023
Blood Cancer Journal

Volume: 13, P: 1-8
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23

Search

Truncation of Kir6.2 produces ATP-sensitive K⁺ channels in the absence of the sulphonylurea receptor

Modulation of dihydropyridine-sensitive Ca²⁺ channels by glucose metabolism in mouse pancreatic β -cells

Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells

Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels

Gating of a muscle K⁺ channel and its dependence on the permeating ion species

Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells

Sweet news for hypoglycemic babies

T-system optical signals associated with inward rectification in skeletal muscle

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

ATP-sensitive K⁺ channels in the hypothalamus are essential for the maintenance of glucose homeostasis

FTO influences adipogenesis by regulating mitotic clonal expansion

Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells

Sulfonylurea improves CNS function in a case of intermediate DEND syndrome caused by a mutation in KCNJ11

K_ATP channels and islet hormone secretion: new insights and controversies

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Overexpression of Fto leads to increased food intake and results in obesity

Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

SARS-CoV-2 evolution during treatment of chronic infection

Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes

From molecule to malady

New insights into K_ATP channel gene mutations and neonatal diabetes mellitus

Evaluating inositol phospholipid interactions with inward rectifier potassium channels and characterising their role in disease

R-type Ca²⁺-channel-evoked CICR regulates glucose-induced somatostatin secretion

Delayed diagnosis resulting in increased disease burden in multiple myeloma: the legacy of the COVID-19 pandemic

Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

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