Nature Search

ATM kinase sustains HER2 tumorigenicity in breast cancer

ATM is a tumour suppressor activated in response to DNA damage. Here, the authors unveil a new tumour-promoting role for ATM in HER2-driven breast cancers, and show that ATM stimulates the interaction between HER2 and HSP90, therefore preventing HER2 from degradation.

Venturina Stagni
Isabella Manni
Daniela Barilà
Research16 Apr 2015
Nature Communications

Volume: 6, P: 1-10
PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding

Although the poly(A) tail and poly(A) binding protein (PABP) have emerged as important effectors of miRNA function, how they contribute to miRNA-mediated gene silencing has been unclear. A combination of biochemical and functional studies now demonstrate that PABP promotes the association of miRISC with its target mRNAs.

Francesca Moretti
Constanze Kaiser
Matthias W Hentze
Research27 May 2012
Nature Structural & Molecular Biology

Volume: 19, P: 603-608
Author Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis

Luigina Romani
Vasilis Oikonomou
Enrico Garaci
Amendments and Corrections22 Jun 2018
Nature Medicine

Volume: 24, P: 1481
Publisher Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis

Luigina Romani
Vasilis Oikonomou
Enrico Garaci
Amendments and Corrections22 Jun 2018
Nature Medicine

Volume: 24, P: 1482
SMURF1 and SMURF2 directly target GLI1 for ubiquitination and proteasome-dependent degradation

Fabio Bordin
Gloria Terriaca
Enrico De Smaele
ResearchOpen Access18 Dec 2024
Cell Death Discovery

Volume: 10, P: 1-12
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

ERAP1 is an endoplasmic reticulum aminopeptidase that trims MHC Class-I peptides for antigen presentation. Here, the authors show that ERAP1 enhances Hedgehog signalling by sequestering USP47 from βTrCP and promoting tumorigenesis through βTrCP degradation and increased Gli protein stability.

Francesca Bufalieri
Paola Infante
Lucia Di Marcotullio
ResearchOpen Access24 Jul 2019
Nature Communications

Volume: 10, P: 1-15
Narratives shaping the protein transition

The protein transition seeks to mitigate the adverse impacts of production and consumption of animal-sourced foods. Three diverse but partially overlapping narratives emerge from the scientific literature, addressing drivers of change, actionable pathways and visions for the future.

Francesca Galli
Michele Moretti
News & Views09 Jan 2024
Nature Food

Volume: 5, P: 7-8
High-resolution crystal structure of a 20 kDa superfluorinated gold nanocluster

The synthesis of atomically precise gold nanoclusters is highly desired for fundamental studies and applications. Here, the authors report the formation of a superfluorinated gold nanocluster stabilized by a multi-branched highly fluorinated thiol ligand, and characterize its crystal structure and molecule-like spectroscopic properties.

Claudia Pigliacelli
Angela Acocella
Giancarlo Terraneo
ResearchOpen Access11 May 2022
Nature Communications

Volume: 13, P: 1-8
Fluopack screening platform for unbiased cellular phenotype profiling

Zhao B. Kang
Ioannis Moutsatsos
Christophe Antczak
ResearchOpen Access07 Feb 2020
Scientific Reports

Volume: 10, P: 1-6
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

3-hydroxy-L-kynurenamine (3-HKA) is a metabolite deriving from a lateral pathway of tryptophan catabolism. Here the authors identify 3-HKA as a biogenic amine and show it has anti-inflammatory properties that can protect mice against psoriasis and nephrotoxic nephritis.

Cristina C. Clement
Angelo D’Alessandro
Laura Santambrogio
ResearchOpen Access21 Jul 2021
Nature Communications

Volume: 12, P: 1-17
Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis

Thymosin α1 is used in the clinic as a treatment in viral disease and acts as an anti-inflammatory. Here it was found to also correct the misfolding of mutant CTFR and potentiate its activity, thus improving outcome in a mouse model of cystic fibrosis.

Luigina Romani
Vasilis Oikonomou
Enrico Garaci
Research10 Apr 2017
Nature Medicine

Volume: 23, P: 590-600
MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts

Francesca Gentiletti
Francesca Mancini
Fabiola Moretti
Research12 Feb 2002
Oncogene

Volume: 21, P: 867-877
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Enabling sensitive and precise detection of ctDNA through somatic copy number aberrations in breast cancer

Riccardo Scandino
Agostina Nardone
Alessandro Romanel
ResearchOpen Access08 Mar 2025
npj Breast Cancer

Volume: 11, P: 1-12
Targeting MDM2 affects spastin protein levels and functions: implications for HSP treatment

Francesca Sardina
Federica Polverino
Cinzia Rinaldo
ResearchOpen Access07 Feb 2025
Cell Death Discovery

Volume: 11, P: 1-9
SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors

Marialaura Petroni
Maria Sahùn Roncero
Giuseppe Giannini
ResearchOpen Access23 Dec 2019
Scientific Reports

Volume: 9, P: 1-15
DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest

Stefania Vossio
Emanuele Palescandolo
Antonio Costanzo
Research24 May 2002
Oncogene

Volume: 21, P: 3796-3803
A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors

Stefano Di Giulio
Valeria Colicchia
Marialaura Petroni
ResearchOpen Access10 Sept 2021
Oncogene

Volume: 40, P: 6143-6152
SALL4 is a CRL3^REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma

Ludovica Lospinoso Severini
Elena Loricchio
Lucia Di Marcotullio
ResearchOpen Access07 Dec 2023
Cell Death & Differentiation

Volume: 31, P: 170-187
Towards more predictive and interdisciplinary climate change ecosystem experiments

Ecosystem response to climate change will vary in amplitude and dynamically, which may not be captured in current experimental design. This Perspective presents experimental design improvements to better predict responses and thus facilitate understanding of future impacts.

Francois Rineau
Robert Malina
Jaco Vangronsveld
Reviews28 Oct 2019
Nature Climate Change

Volume: 9, P: 809-816
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation

Sonia Coni
Silvia Maria Serrao
Gianluca Canettieri
ResearchOpen Access10 Dec 2020
Cell Death & Disease

Volume: 11, P: 1-14
KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2

Eleonora Spiombi
Annapaola Angrisani
Enrico De Smaele
ResearchOpen Access04 Nov 2019
Oncogenesis

Volume: 8, P: 1-11
A p38-dependent pathway regulates ΔNp63 DNA binding to p53-dependent promoters in UV-induced apoptosis of keratinocytes

Marina Papoutsaki
Francesca Moretti
Antonio Costanzo
Research20 Jun 2005
Oncogene

Volume: 24, P: 6970-6975
Author Correction: Cluster-assembled zirconia substrates promote long-term differentiation and functioning of human islets of Langerhans

Alessandra Galli
Elisa Maffioli
Carla Perego
Amendments and CorrectionsOpen Access27 Nov 2018
Scientific Reports

Volume: 8, P: 1-2
Vector-based RNA interference against vascular endothelial growth factor-A significantly limits vascularization and growth of prostate cancer in vivo

Francesca Wannenes
Silvia Anna Ciafré
Maria Giulia Farace
Research27 May 2005
Cancer Gene Therapy

Volume: 12, P: 926-934
Ischemic wound revascularization by the stromal vascular fraction relies on host-donor hybrid vessels

Roman Vuerich
Elena Groppa
Serena Zacchigna
ResearchOpen Access11 Feb 2023
npj Regenerative Medicine

Volume: 8, P: 1-15
Cluster-assembled zirconia substrates promote long-term differentiation and functioning of human islets of Langerhans

Alessandra Galli
Elisa Maffioli
Carla Perego
ResearchOpen Access02 Jul 2018
Scientific Reports

Volume: 8, P: 1-17
Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells

Agnese Po
Anna Citarella
Elisabetta Ferretti
ResearchOpen Access19 Aug 2020
Scientific Reports

Volume: 10, P: 1-14
Sempervirine inhibits RNA polymerase I transcription independently from p53 in tumor cells

Cinzia Caggiano
Eugenia Guida
Susanna Dolci
ResearchOpen Access28 Oct 2020
Cell Death Discovery

Volume: 6, P: 1-15
Catch-and-Release of Target Cells Using Aptamer-Conjugated Electroactive Zwitterionic Oligopeptide SAM

Junko Enomoto
Tatsuto Kageyama
Junji Fukuda
ResearchOpen Access07 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
A geo-chemo-mechanical study of a highly polluted marine system (Taranto, Italy) for the enhancement of the conceptual site model

F. Cotecchia
C. Vitone
V. Corbelli
ResearchOpen Access17 Feb 2021
Scientific Reports

Volume: 11, P: 1-26
Disclosing Jackson Pollock’s palette in Alchemy (1947) by non-invasive spectroscopies

F. Rosi
C. Grazia
C. Miliani
ResearchOpen Access16 Jun 2016
Heritage Science

Volume: 4, P: 1-13
MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response

F Mancini
L Pieroni
F Moretti
ResearchOpen Access11 May 2015
Oncogene

Volume: 35, P: 228-240

Search

ATM kinase sustains HER2 tumorigenicity in breast cancer

PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding

Author Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis

Publisher Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis

SMURF1 and SMURF2 directly target GLI1 for ubiquitination and proteasome-dependent degradation

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

Narratives shaping the protein transition

High-resolution crystal structure of a 20 kDa superfluorinated gold nanocluster

Fluopack screening platform for unbiased cellular phenotype profiling

3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis

MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts

Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Enabling sensitive and precise detection of ctDNA through somatic copy number aberrations in breast cancer

Targeting MDM2 affects spastin protein levels and functions: implications for HSP treatment

SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors

DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest

A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors

SALL4 is a CRL3^REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma

Towards more predictive and interdisciplinary climate change ecosystem experiments

Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation

KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2

A p38-dependent pathway regulates ΔNp63 DNA binding to p53-dependent promoters in UV-induced apoptosis of keratinocytes

Author Correction: Cluster-assembled zirconia substrates promote long-term differentiation and functioning of human islets of Langerhans

Vector-based RNA interference against vascular endothelial growth factor-A significantly limits vascularization and growth of prostate cancer in vivo

Ischemic wound revascularization by the stromal vascular fraction relies on host-donor hybrid vessels

Cluster-assembled zirconia substrates promote long-term differentiation and functioning of human islets of Langerhans

Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells

Sempervirine inhibits RNA polymerase I transcription independently from p53 in tumor cells

Catch-and-Release of Target Cells Using Aptamer-Conjugated Electroactive Zwitterionic Oligopeptide SAM

A geo-chemo-mechanical study of a highly polluted marine system (Taranto, Italy) for the enhancement of the conceptual site model

Disclosing Jackson Pollock’s palette in Alchemy (1947) by non-invasive spectroscopies

MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response

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