Mitotic density is part of breast cancer grading yet is hampered by interobserver variability. The authors developed a deep learning algorithm which automatically locates the mitotic hotspot in breast tumors. Counting mitoses within this predefined hotspot considerably improved interobserver agreement. Mitotic counts assessed by the algorithm were comparable to the observers’ results.
- Maschenka C. A. Balkenhol
- David Tellez
- Jeroen A. W. M. van der Laak
