Nature Search

Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Embedding oral health indicators into multidimensional frailty models

Through biological, functional and psychosocial pathways that include inflammation, malnutrition and social isolation, oral health and disease contributes to systemic aging and frailty. Building on the concept of oral frailty, here we argue that validated oral health indicators — which are widely captured in aging surveys — should be integrated into multidimensional frailty frameworks to improve prediction, early intervention and holistic care for older adults.

Vittorio Dibello
Frank Lobbezoo
Francesco Panza
Comments & Opinion17 Oct 2025
Nature Aging

Volume: 5, P: 2359-2362
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
Age-related hearing impairment—a risk factor and frailty marker for dementia and AD

Age related hearing impairment (ARHI, also known as presbycusis) is an important frailty marker, and could be a reversible risk factor for dementia and Alzheimer disease. Poor verbal communication and depletion of cognitive reserve might causally link ARHI to cognitive decline and frailty; hearing aids and cognitive training might, thus, provide a strategy to delay or prevent cognitive deterioration. In this Review, Panza and colleagues discuss the interplay between cognitive impairment, ARHI and frailty in older age.

Francesco Panza
Vincenzo Solfrizzi
Giancarlo Logroscino
Reviews17 Feb 2015
Nature Reviews Neurology

Volume: 11, P: 166-175
Development of disease-modifying drugs for frontotemporal dementia spectrum disorders

In this Review, Panza and colleagues provide an overview of the current understanding of pathogenic mechanisms of frontotemporal dementia spectrum disorders and discuss how this knowledge is driving the development of potential disease-modifying drugs.

Francesco Panza
Madia Lozupone
Bruno P. Imbimbo
Reviews23 Mar 2020
Nature Reviews Neurology

Volume: 16, P: 213-228
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Bin Zhou
Kate E. Sheffer
Majid Ezzati
ResearchOpen Access09 Nov 2023
Nature Medicine

Volume: 29, P: 2885-2901
Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
An explosive component in a December 2020 Milan earthquake suggests outgassing of deeply recycled carbon

A deep, magnitude 4.6 earthquake, beneath Milan, Italy, in December 2020 involved a major explosive component that may indicate outgassing of carbon dioxide from ascending carbonate-rich melts, according to moment tensor inversion of the seismic source.

Marco Giovanni Malusà
Enrico Brandmayr
Maria Luce Frezzotti
ResearchOpen Access10 Jan 2022
Communications Earth & Environment

Volume: 3, P: 1-6
The challenges of anti-tau therapeutics in Alzheimer disease

A phase II trial of the tau antibody semorinemab indicates that it has no clinical benefit in the earliest stages of Alzheimer disease. The repeated finding that antibody-mediated reductions in protein pathology have limited or no clinical benefit indicates that we need to consider more specific or combined therapeutic targets.

Francesco Panza
Madia Lozupone
News & Views08 Aug 2022
Nature Reviews Neurology

Volume: 18, P: 577-578
Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer’s disease

Maria Carolina Dalmasso
Luis Ignacio Brusco
Alfredo Ramirez
ResearchOpen Access31 Jan 2019
Translational Psychiatry

Volume: 9, P: 1-6
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

Philippe Amouyel and colleagues report a genome-wide association study for Alzheimer's disease. They identify variants within CLU and CR1 associated with susceptibility to late-onset Alzheimer's disease.

Jean-Charles Lambert
Simon Heath
Philippe Amouyel
Research06 Sept 2009
Nature Genetics

Volume: 41, P: 1094-1099
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.

Rebecca Sims
Sven J van der Lee
Gerard D Schellenberg
Research17 Jul 2017
Nature Genetics

Volume: 49, P: 1373-1384
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

Julie Williams, Michael Owen and colleagues report staged follow-up and meta-analyses of genome-wide association studies for Alzheimer's disease from the GERAD+ consortium. They identify common variants at ABCA7 and MS4A6A/MS4A4E associated with Alzheimer's disease and support for several additional susceptibility loci.

Paul Hollingworth
Denise Harold
Julie Williams
Research03 Apr 2011
Nature Genetics

Volume: 43, P: 429-435
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Philippe Amouyel, Julie Williams, Gerard Schellenberg, Sudha Seshadri and colleagues report a meta-analysis of genome-wide association studies for late-onset Alzheimer's disease in 17,008 cases and 37,154 controls with replication in an additional 8,572 cases and 11,312 controls. They identify 11 loci newly associated with Alzheimer's disease.

Jean-Charles Lambert
Carla A Ibrahim-Verbaas
Philippe Amouyel
Research27 Oct 2013
Nature Genetics

Volume: 45, P: 1452-1458
A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

Potential disease-modifying therapies for Alzheimer disease have mostly targeted brain accumulation of amyloid-β, but this approach has yet to provide substantial clinical benefits. The authors consider the reasons for this failure and suggest alternative strategies, including modification of risk factors.

Francesco Panza
Madia Lozupone
Bruno P. Imbimbo
Reviews04 Jan 2019
Nature Reviews Neurology

Volume: 15, P: 73-88
Privacy-friendly evaluation of patient data with secure multiparty computation in a European pilot study

Hendrik Ballhausen
Stefanie Corradini
Sebastian Marschner
ResearchOpen Access14 Oct 2024
npj Digital Medicine

Volume: 7, P: 1-12
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Amendments and Corrections15 Aug 2019
Nature Genetics

Volume: 51, P: 1423-1424
A family history of type 2 diabetes as a predictor of fatty liver disease in diabetes-free individuals with excessive body weight

Giovanni De Pergola
Fabio Castellana
Gianluigi Giannelli
ResearchOpen Access16 Dec 2021
Scientific Reports

Volume: 11, P: 1-8
Active carbon sequestration in the Alpine mantle wedge and implications for long-term climate trends

Marco Giovanni Malusà
Maria Luce Frezzotti
Giuliano Francesco Panza
ResearchOpen Access16 Mar 2018
Scientific Reports

Volume: 8, P: 1-8
A novel Alzheimer disease locus located near the gene encoding tau protein

G Jun
C A Ibrahim-Verbaas
L A Farrer
Research17 Mar 2015
Molecular Psychiatry

Volume: 21, P: 108-117

Search

Diminishing benefits of urban living for children and adolescents’ growth and development

Embedding oral health indicators into multidimensional frailty models

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Age-related hearing impairment—a risk factor and frailty marker for dementia and AD

Development of disease-modifying drugs for frontotemporal dementia spectrum disorders

Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Repositioning of the global epicentre of non-optimal cholesterol

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

An explosive component in a December 2020 Milan earthquake suggests outgassing of deeply recycled carbon

The challenges of anti-tau therapeutics in Alzheimer disease

Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer’s disease

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

Privacy-friendly evaluation of patient data with secure multiparty computation in a European pilot study

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

A family history of type 2 diabetes as a predictor of fatty liver disease in diabetes-free individuals with excessive body weight

Active carbon sequestration in the Alpine mantle wedge and implications for long-term climate trends

A novel Alzheimer disease locus located near the gene encoding tau protein

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