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Showing 1–3 of 3 results
Advanced filters: Author: Francisca Sivera Clear advanced filters

    • Eliseo Pascual
    • Francisca Sivera
    • Peter Kirkpatrick
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 8, P: 191-192

  • Gout is caused by the precipitation of monosodium urate monohydrate (MSU) crystals in the joints and in other tissues. Although direct observations of MSU crystals as they form on tissues are lacking, morphological findings and comparison with the physiological process of biomineralization suggests possible mechanisms of pathological MSU crystal formation and the conditions that might favour the nucleation and growth of crystals at particular anatomical sites.

    • Eliseo Pascual
    • Lia Addadi
    • Francisca Sivera
    Reviews
    Nature Reviews Rheumatology
    Volume: 11, P: 725-730

  • A multi-analytical study of MSU crystals in synovial fluid of gouty patients discloses distinctive textural and ultrastructural features which are not present in abiotic MSU crystals, offering new clues to understand their pathological formation.

    • Carlos Rodriguez-Navarro
    • Kerstin Elert
    • Encarnación Ruiz-Agudo
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-11