Nature Search

Space radiation damage rescued by inhibition of key spaceflight associated miRNAs

In space radiation-exposed cells, targeting specific microRNAs with antagomirs can reduce cardiovascular damage and improve cellular function. Here the authors describe a reduction in inflammation and DNA double-strand break activity within these cells upon antagomir treatment.

J. Tyson McDonald
JangKeun Kim
Afshin Beheshti
ResearchOpen Access11 Jun 2024
Nature Communications

Volume: 15, P: 1-23
sChemNET: a deep learning framework for predicting small molecules targeting microRNA function

Here the authors developed and experimentally validated sChemNET, a deep learning framework to predict small molecules affecting microRNA function based on chemical structure and sequence data. sChemNET predicts bioactive small molecules on the basis of sparse chemical datasets.

Diego Galeano
Imrat
Afshin Beheshti
ResearchOpen Access23 Oct 2024
Nature Communications

Volume: 15, P: 1-16
Plasmodium translocon component EXP2 facilitates hepatocyte invasion

While the role of Plasmodium EXP2 protein as translocon component of blood stage parasites is established, its functional role in liver stage parasites remains unclear. Here, Mello-Vieira et al. reveal that EXP2 pore-forming activity induces hepatocyte membrane repair and hence is critical for hepatocyte invasion.

João Mello-Vieira
Francisco J. Enguita
Maria M. Mota
ResearchOpen Access06 Nov 2020
Nature Communications

Volume: 11, P: 1-13
MiR-146b negatively regulates migration and delays progression of T-cell acute lymphoblastic leukemia

Nádia C. Correia
Rita Fragoso
João T. Barata
ResearchOpen Access23 Aug 2016
Scientific Reports

Volume: 6, P: 1-10
New LncRNAs in Chronic Hepatitis C progression: from fibrosis to hepatocellular carcinoma

Adriana Camargo Ferrasi
Geysson Javier Fernandez
Maria Inês de Moura Campos Pardini
ResearchOpen Access18 Jun 2020
Scientific Reports

Volume: 10, P: 1-9
To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants

A circulating miRNA signature linked to birth defect risk, (i.e. as small-for-gestational-age (SGA) fetuses), was identified for females exposed to the space environment. AI/ML tools were used to predict potential countermeasures to mitigate this risk. @AfshinBeheshti @PittTweet

Giada Corti
JangKeun Kim
Afshin Beheshti
ResearchOpen Access05 Oct 2024
Communications Biology

Volume: 7, P: 1-22
Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes

To evade autophagy-mediated killing when inside liver cells, the Plasmodium berghei protein UIS3 binds to a key regulator of the autophagy programme, the host protein LC3, and inhibits its interaction with downstream effectors.

Eliana Real
Lénia Rodrigues
Maria M. Mota
Research06 Nov 2017
Nature Microbiology

Volume: 3, P: 17-25
Disrupting Plasmodium UIS3–host LC3 interaction with a small molecule causes parasite elimination from host cells

Sonali Setua et al. identify a small molecule which is capable of disrupting the interaction between the plasmodium-derived protein UIS3 and the host protein LC3. Disruption of this interaction by this small molecule triggers parasite elimination from host cells in an autophagy-dependent manner, without affecting the cells’ normal autophagy pathway.

Sonali Setua
Francisco J. Enguita
Maria M. Mota
ResearchOpen Access19 Nov 2020
Communications Biology

Volume: 3, P: 1-10
Author Correction: To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants

Giada Corti
JangKeun Kim
Afshin Beheshti
Amendments and CorrectionsOpen Access16 Oct 2024
Communications Biology

Volume: 7, P: 1
A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection

S. Anand Narayanan
David A. Jamison Jr
Afshin Beheshti
ReviewsOpen Access08 Nov 2023
European Journal of Human Genetics

Volume: 32, P: 10-20
The circulating non-coding RNA landscape for biomarker research: lessons and prospects from cardiovascular diseases

Stępień E
Marina C Costa
Francisco J Enguita
Reviews07 Jun 2018
Acta Pharmacologica Sinica

Volume: 39, P: 1085-1099

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Space radiation damage rescued by inhibition of key spaceflight associated miRNAs

sChemNET: a deep learning framework for predicting small molecules targeting microRNA function

Plasmodium translocon component EXP2 facilitates hepatocyte invasion

MiR-146b negatively regulates migration and delays progression of T-cell acute lymphoblastic leukemia

New LncRNAs in Chronic Hepatitis C progression: from fibrosis to hepatocellular carcinoma

To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants

Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes

Disrupting Plasmodium UIS3–host LC3 interaction with a small molecule causes parasite elimination from host cells

Author Correction: To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants

A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection

The circulating non-coding RNA landscape for biomarker research: lessons and prospects from cardiovascular diseases

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