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Showing 1–7 of 7 results

Advanced filters: Author: Francisco Sadras Clear advanced filters

CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphoma

Pathological B-cell receptor (BCR) signaling is a key driver of mantle cell lymphoma tumorigenesis. Here, the authors discover that CEACAM1, an immunoglobulin-like transmembrane protein, is essential for a subset of mantle cell lymphoma through activation of the BCR.

Serene Xavier
Vivian Nguyen
Vu N. Ngo
ResearchOpen Access29 May 2025
Nature Communications

Volume: 16, P: 1-18
Remodeling of calcium signaling and store operated calcium entry as a consequence of human neural progenitor cell differentiation

Silke B. Chalmers
Mélanie Robitaille
Gregory R. Monteith
ResearchOpen Access06 Nov 2025
Scientific Reports

Volume: 15, P: 1-12
Signalling input from divergent pathways subverts B cell transformation

Analysis of B-cell leukaemia samples reveals that oncogenic mutations do not cause malignant transformation unless they converge on the same signalling pathway, and that it may be possible clinically to combine inhibition of the principal oncogenic driver with reactivation of divergent pathways.

Lai N. Chan
Mark A. Murakami
Markus Müschen
Research22 Jul 2020
Nature

Volume: 583, P: 845-851
IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells

IFITM3 shifts upon phosphorylation from acting as an antiviral effector to being a scaffold for PIP3 and thereby amplifies PI3K signalling, which can be co-opted for malignant transformation in B cell leukaemia and lymphoma.

Jaewoong Lee
Mark E. Robinson
Markus Müschen
Research04 Nov 2020
Nature

Volume: 588, P: 491-497
Author Correction: IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells

Jaewoong Lee
Mark E. Robinson
Markus Müschen
Amendments and Corrections12 Mar 2021
Nature

Volume: 592, P: E3
Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells

A multidisciplinary approach suggests the importance of cellular geometry in modulating calcium signals in breast cancer cells via the PIEZO1 force sensing channel which is also associated with breast cancer cell plasticity.

Choon Leng So
Mélanie Robitaille
Gregory R. Monteith
ResearchOpen Access17 Apr 2024
Communications Biology

Volume: 7, P: 1-14
Autoimmunity checkpoints as therapeutic targets in B cell malignancies

Recent studies have suggested that autoimmunity checkpoints (AICs) are fully functional in B cell leukaemias and lymphomas, despite malignant transformation. This Opinion article proposes that targeted engagement of AICs might represent a therapeutic opportunity to overcome drug resistance in B cell malignancies.

Markus Müschen
Reviews05 Jan 2018
Nature Reviews Cancer

Volume: 18, P: 103-116