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Showing 1–7 of 7 results
Advanced filters: Author: Francisco Verdeguer Clear advanced filters

  • Here, the authors show that MacroD1 is important for mitochondrial integrity and function. Lack of MacroD1 resulted in impaired cellular respiration which was particularly detrimental for cells and organs with high energetic requirements, such as skeletal muscle.

    • Ann-Katrin Hopp
    • Lorenza P. Ferretti
    • Michael O. Hottiger
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Molecular factors, regulating the expression of specific glycolytic enzymes that favour biosynthetic processes, have remained unknown. Panasyuket al. identify PPARγ as a novel transcription factor turning on pyruvate kinase M2 and hexokinase 2, which are frequently upregulated in pathophysiological growth.

    • Ganna Panasyuk
    • Catherine Espeillac
    • Mario Pende
    ResearchOpen Access
    Nature Communications
    Volume: 3, P: 1-9

  • Proinflammatory activation of liver macrophages and their secretion of proinflammatory cytokines have been linked to obesity. Here Morgantini et al. report a mechanism through which liver macrophages can impair liver metabolism and promote insulin resistance in obesity in the absence of an overt proinflammatory phenotype, through secretion of non-inflammatory factors such as IGFBP7.

    • Cecilia Morgantini
    • Jennifer Jager
    • Myriam Aouadi
    Research
    Nature Metabolism
    Volume: 1, P: 445-459

  • Deficiency of the transcription factor HNF-1β results in kidney cyst formation. Marco Pontoglio and his colleagues now show that HNF-1β normally remains bound to condensed chromatin during mitosis to facilitate the rapid expression of key genes involved in cell quiescence post-mitosis. In the absence of HNF-1β, these genes fail to express, and the kidney epithelial cells continue to proliferate, resulting in cysts.

    • Francisco Verdeguer
    • Stephanie Le Corre
    • Marco Pontoglio
    Research
    Nature Medicine
    Volume: 16, P: 106-110

  • Brown or beige fat activation can cause potent anti-obesity and anti-diabetic effects. In a study recently published in Nature, Gnad et al. show that adenosine is a novel activator of brown and beige fat that acts through the A2A receptor.

    • Amy K Rines
    • Francisco Verdeguer
    • Pere Puigserver
    Research Highlights
    Cell Research
    Volume: 25, P: 155-156