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Showing 1–8 of 8 results
Advanced filters: Author: Franco Cecchi Clear advanced filters
  • Hypertrophic cardiomyopathy is a widespread condition that is often neglected and undiagnosed. Although there are still large gaps in our knowledge of the basic disease mechanisms, population studies have shown us that patients can have normal life expectancy but often develop disease-related complications. In this Viewpoint, Franco Cecchi, Magdi Yacoub and Iacopo Olivotto highlight the disease's screening and treatment, and some of the exciting new knowledge in the field.

    • Franco Cecchi
    • Magdi H Yacoub
    • Iacopo Olivotto
    Reviews
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 2, P: 324-325
  • 'End-stage' hypertrophic cardiomyopathy (HCM) is one of the most serious manifestations of HCM, yet its etiology remains poorly understood. Here, Yacoub et al. discuss recent advances in our knowledge of end-stage HCM, explore avenues for future research, and propose that elucidating this 'mysterious' condition might provide a model for other myocardial diseases.

    • Magdi H Yacoub
    • Iacopo Olivotto
    • Franco Cecchi
    Reviews
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 4, P: 232-233
  • In this fascinating Perspective article, the authors propose a novel hypothesis for the developmental origin of the variable phenotypes seen in hypertrophic cardiomyopathy (HCM). They suggest that cross-talk between healthy epicardium-derived cells and abnormally contracting cardiomyocytes could account for the extramyocardial manifestations of HCM, by a putative mechanism of mechanotransduction leading to abnormal gene expression and cell differentiation.

    • Iacopo Olivotto
    • Franco Cecchi
    • Magdi H. Yacoub
    Reviews
    Nature Reviews Cardiology
    Volume: 6, P: 317-321
  • Genetic cardiomyopathies are complex diseases with heterogeneous clinical presentations and phenotypes, and mild pathology can overlap with physiological variation, particularly in athletes. In this Review, three of the most common and controversial areas are discussed, including left ventricular hypertrophy; left ventricular dilatation, noncompaction, and fibrosis; and arrhythmias originating from the right ventricle.

    • Giovanni Quarta
    • Michael Papadakis
    • Iacopo Olivotto
    Reviews
    Nature Reviews Cardiology
    Volume: 14, P: 102-112