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Showing 1–15 of 15 results
Advanced filters: Author: Frank Bradke Clear advanced filters

  • Adult mammalian CNS axons show little regenerative capacity following injury, in part because they fail to assemble functional growth cones at their tips. However, axons from the mammalian peripheral nervous system and non-mammalian species show more regenerative potential. Here, Bradkeet al. examine the process of growth cone assembly after axonal injury. Understanding why this process does not always succeed may facilitate the development of treatments for CNS-damage-related disability.

    • Frank Bradke
    • James W. Fawcett
    • Micha E. Spira
    Reviews
    Nature Reviews Neuroscience
    Volume: 13, P: 183-193

  • Current approaches for live imaging of cellular actin dynamics have several drawbacks. Now the use of Lifeact, a 17-aa actin-binding peptide from yeast that is not present in higher eukaryotes, allows imaging of actin dynamics in live mammalian cells without disruption of function and without competition with endogenous binding proteins.

    • Julia Riedl
    • Alvaro H Crevenna
    • Roland Wedlich-Soldner
    Research
    Nature Methods
    Volume: 5, P: 605-607

  • Whether class V myosins can work as point-to-point transporters in animal cells is highly debated. Myosin-Va is now shown to function as a point-to-point transporter that pulls the endoplasmic reticulum (ER) into dendritic spines, with important consequences for dendritic development and cerebellar motor learning.

    • Michael Stiess
    • Frank Bradke
    News & Views
    Nature Cell Biology
    Volume: 13, P: 10-11

  • Ali Ertürk and colleagues present a novel tetrahydrofuran-based histological tissue clearing procedure that renders fixed and unsectioned adult CNS tissue (spinal cord and brainstem) transparent and, as such, fully amenable to a range of different optical imaging techniques. This three-dimensional imaging method can be used for studying axon regeneration and glial reactions.

    • Ali Ertürk
    • Christoph P Mauch
    • Frank Bradke
    Research
    Nature Medicine
    Volume: 18, P: 166-171

  • Microtubule dynamics in neurons play critical roles in physiology, injury and disease. Here the authors develop a transgenic mouse line expressing a fluorescently tagged version of the microtubule binding protein EB3, and using a range of imaging techniques, study microtubule dynamics under normal and injury conditions in living mice.

    • Tatjana Kleele
    • Petar Marinković
    • Thomas Misgeld
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-10

  • Epigenetic codes translate external stimuli into targeted and long-lasting gene regulation. In this study, the authors show that regenerative retrograde signalling activates the epigenetic modifying enzyme PCAF, inducing gene expression and promoting axon regeneration in a mouse spinal cord injury model.

    • Radhika Puttagunta
    • Andrea Tedeschi
    • Simone Di Giovanni
    Research
    Nature Communications
    Volume: 5, P: 1-13

  • During their maturation, mammalian neurons lose the capacity to regrow their axons after an injury. Here, Hilton et al. explore the neuron maturation processes that limit axon regeneration, including changes in gene expression, cytoskeletal dynamics, and intracellular signalling and trafficking.

    • Brett J. Hilton
    • Jarred M. Griffin
    • Frank Bradke
    Reviews
    Nature Reviews Neuroscience
    Volume: 25, P: 649-667

  • Spinal cord injury causes life-threatening infections. The authors report that this is partially mediated by a maladaptive neuroendocrine reflex, extending from the spinal cord to the adrenal glands, where it blocks catecholamines while producing immunosuppressive corticosteroids. The effect depends on the spinal injury level, and normalization of hormones production by the adrenals rescued mice from pneumonia.

    • Harald Prüss
    • Andrea Tedeschi
    • Jan M Schwab
    Research
    Nature Neuroscience
    Volume: 20, P: 1549-1559

  • The interphase centrosome protein AKNA is necessary and sufficient for the organization of centrosomal microtubules, mediates delamination in the formation of the subventricular zone and regulates exit from this zone.

    • Germán Camargo Ortega
    • Sven Falk
    • Magdalena Götz
    Research
    Nature
    Volume: 567, P: 113-117

  • The authors describe a glutamatergic septoentorhinal pathway that provides running-speed-correlated input to MEC layer 2/3. The speed signal is integrated by several MEC cell classes and converted into speed-dependent output. This speed circuit may be important for the spatial computations of MEC neurons.

    • Daniel Justus
    • Dennis Dalügge
    • Stefan Remy
    Research
    Nature Neuroscience
    Volume: 20, P: 16-19