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Showing 1–4 of 4 results

Advanced filters: Author: Frank D. Teets Clear advanced filters

Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks

Computational methods are becoming an increasingly important part of biological research. Using the Rosetta framework as an example, the authors demonstrate how community-driven development of computational methods can be done in a reproducible and reliable fashion.

Julia Koehler Leman
Sergey Lyskov
Richard Bonneau
ResearchOpen Access29 Nov 2021
Nature Communications

Volume: 12, P: 1-15
Macromolecular modeling and design in Rosetta: recent methods and frameworks

This Perspective reviews tools developed over the past five years in the macromolecular modeling, docking and design software Rosetta.

Julia Koehler Leman
Brian D. Weitzner
Richard Bonneau
Reviews01 Jun 2020
Nature Methods

Volume: 17, P: 665-680
Author Correction: Optogenetic control of cofilin and αTAT in living cells using Z-lock

Orrin J. Stone
Neha Pankow
Klaus M. Hahn
Amendments and Corrections21 Jul 2020
Nature Chemical Biology

Volume: 16, P: 1034
Optogenetic control of cofilin and αTAT in living cells using Z-lock

Z-lock is introduced as a new method to control protein activity with light. It relies on a steric block placed over important regions of the target protein that can be released reversibly. Z-lock was applied to regulate cofilin and αTAT activity.

Orrin J. Stone
Neha Pankow
Klaus M. Hahn
Research18 Nov 2019
Nature Chemical Biology

Volume: 15, P: 1183-1190