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Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells

Depuydt and Schaftenaar et al. profile the T cell clonality in patients with atherosclerosis by performing single-cell T cell receptor sequencing on carotid artery plaques and matched peripheral blood mononuclear cell samples. The analyses showed plaque-specific clonal expansion in effector CD4⁺ T cells, expressing genes indicative of exposure to activating antigens, thus suggesting that atherosclerosis has an autoimmune component driven by autoreactive CD4⁺ T cells.

Marie A. C. Depuydt
Frank H. Schaftenaar
Bram Slütter
ResearchOpen Access30 Jan 2023
Nature Cardiovascular Research

Volume: 2, P: 112-125
An immunodominant NP_105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

Peng et al. find that immunodominant cytotoxic T lymphocytes (CTLs) specific for NP_105–113-B*07:02 are associated with reduced COVID-19 severity. Mechanistically, NP_105–113-B*07:02-specific CTLs show potent antiviral functionality and may represent rational T cell vaccine targets.

Yanchun Peng
Suet Ling Felce
Tao Dong
ResearchOpen Access01 Dec 2021
Nature Immunology

Volume: 23, P: 50-61
Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis

Psoriatic arthritis (PsA) commonly affects patients with skin psoriasis, but its pathogenesis is still unclear. Here the authors use two types of single-cells data, mass cytometry and RNA sequencing, to describe the expansion and diversity of synovial, but not peripheral blood, CD8 T cells from PsA patients to provide a molecular immune landscape for PsA.

Frank Penkava
Martin Del Castillo Velasco-Herrera
M. Hussein Al-Mossawi
ResearchOpen Access21 Sept 2020
Nature Communications

Volume: 11, P: 1-11
Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates

Simone et al. analyze T cell receptor usage and gene expression profiles of CD3+CD45RA-CD25+CD127low blood and synovial fluid regulatory T cells from patients with spondyloarthritis. This work provides a valuable resource for understanding regulatory T cell heterogeneity and transcriptional adaptation in an immune-driven condition.

Davide Simone
Frank Penkava
Paul Bowness
ResearchOpen Access14 Dec 2021
Communications Biology

Volume: 4, P: 1-15
The novel MKL target gene myoferlin modulates expansion and senescence of hepatocellular carcinoma

C Hermanns
V Hampl
S Muehlich
Research23 Jan 2017
Oncogene

Volume: 36, P: 3464-3476

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Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells

An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis

Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates

The novel MKL target gene myoferlin modulates expansion and senescence of hepatocellular carcinoma

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An immunodominant NP_105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease