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Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8

HDAC8 counteracts the conversion of sensory Schwann cells into their repair phenotype by controlling hypoxia-induced c-Jun upregulation after injury. Ablating HDAC8 accelerates the regrowth of sensory axons and the recovery of the sensory function.

Nadège Hertzog
Mert Duman
Claire Jacob
ResearchOpen Access09 Jan 2025
Nature Communications

Volume: 16, P: 1-16

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Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8

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