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Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex

Karalis et al show that genetic reduction of the mTORC1 component Raptor improves multiple phenotypes in mouse models of TSC. Their findings suggest that Raptor could be a potential therapeutic target for treating the neurological aspects of TSC.

Vasiliki Karalis
Franklin Caval-Holme
Helen S. Bateup
ResearchOpen Access09 Aug 2022
Nature Communications

Volume: 13, P: 1-20

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Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex

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