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  • Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory respiratory disease characterized by airflow limitation and infective exacerbations. Here, Chan et al. report the generation of nasopharyngeal and bronchial COPD organoids derived from adult stem cells and employ them in the study of host-pathogen interactions, including SARS-CoV-2 and Pseudomonas aeruginosa.

    • Louisa L. Y. Chan
    • Danielle E. Anderson
    • Sanjay H. Chotirmall
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Integrated analysis of bacterial, fungal and microbial communities in the airways of patients with bronchiectasis demonstrates that interaction networks, rather than the relative abundance of any single microbial species, are associated with exacerbation risk.

    • Micheál Mac Aogáin
    • Jayanth Kumar Narayana
    • Sanjay H. Chotirmall
    Research
    Nature Medicine
    Volume: 27, P: 688-699