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Showing 1–5 of 5 results
Advanced filters: Author: Franziska Bleichert Clear advanced filters

  • Biochemical and structural studies of the loading pathway of the human MCM2–7 replicative helicase motor reveal differences from the orthologous yeast system that may increase resilience against challenges faced by multicellular organisms.

    • Ran Yang
    • Olivia Hunker
    • Franziska Bleichert
    Research
    Nature
    Volume: 636, P: 488-498

  • The origin recognition complex (ORC) is essential for loading the Mcm2–7 replicative helicase onto DNA during DNA replication initiation. Here, the authors describe several cryo-electron microscopy structures of Drosophila ORC bound to DNA and its cofactor Cdc6 and also report an in vitro reconstitution system for Drosophila Mcm2–7 loading, revealing unexpected features of ORC’s DNA binding and remodeling mechanism during Mcm2–7 loading.

    • Jan Marten Schmidt
    • Franziska Bleichert
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Cellular lysine residues can be both methylated and acetylated on the same sidechain to form Nε-acetyl-Nε-methyllysine (Kacme), which is found on histone H4 across a range of species and across mammalian tissues and is associated with active chromatin.

    • William J. Lu-Culligan
    • Leah J. Connor
    • Matthew D. Simon
    Research
    Nature
    Volume: 622, P: 173-179

  • The crystal structure of the heterohexameric origin recognition complex (ORC), essential for coordinating DNA replication onset in eukaryotes, is resolved at 3.5 Å resolution.

    • Franziska Bleichert
    • Michael R. Botchan
    • James M. Berger
    Research
    Nature
    Volume: 519, P: 321-326