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FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains

FUT10 and FUT11, originally annotated as α1,3-fucosyltransferases, are actually protein O-fucosyltransferases participating in a non-canonical ER quality control pathway for EMI domain-containing protein secretion.

Huilin Hao
Youxi Yuan
Robert S. Haltiwanger
ResearchOpen Access07 Jan 2025
Nature Chemical Biology

Volume: 21, P: 598-610
Clinical response to azacitidine in MDS is associated with distinct DNA methylation changes in HSPCs

Azacitidine (AZA) response in myelodysplastic neoplasms is unpredictable. Here, the authors show in a phase 2 trial that while global methylation changes did not differ by response, baseline and initial CpG methylation differences in HSPCs predicted AZA response.

Julie A. I. Thoms
Feng Yan
John E. Pimanda
ResearchOpen Access13 May 2025
Nature Communications

Volume: 16, P: 1-20
Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

The pathogenesis of heparin-induced thrombocytopenia and thrombosis (HIT) is mediated by heparin-reactive autoantibodies binding to platelets (thrombocytes). Here the authors show neutrophil activation and NETosis are elevated in patients with HIT, and are essential for thrombosis in HIT mouse models.

José Perdomo
Halina H. L. Leung
Beng H. Chong
ResearchOpen Access21 Mar 2019
Nature Communications

Volume: 10, P: 1-14
Βeta 2-glycoprotein I protects mice against gram-negative septicaemia in a sexually dimorphic manner

Fatima El-Assaad
Miao Qi
Steven Anthony Krilis
ResearchOpen Access15 Aug 2017
Scientific Reports

Volume: 7, P: 1-11

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FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains

Clinical response to azacitidine in MDS is associated with distinct DNA methylation changes in HSPCs

Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

Βeta 2-glycoprotein I protects mice against gram-negative septicaemia in a sexually dimorphic manner

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