Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Frederike J. Klein Clear advanced filters

  • Genetic variants associated with susceptibility to pancreatic cancer have been identified using genome wide association studies (GWAS). Here, the authors combine data from over 9000 patients and perform a meta-analysis to identify five novel loci linked to pancreatic cancer.

    • Alison P. Klein
    • Brian M. Wolpin
    • Laufey T. Amundadottir
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • The mechanisms of intratumoral subtype heterogeneity in pancreatic ductal adenocarcinoma (PDAC) remain unclear. Here, the authors analyse PDAC tumours and preclinical models using multi-omics and imaging; they demonstrate that AP1 dichotomy influences tumor plasticity, heterogeneity, and immune response, with potential therapeutic implications.

    • Lukas Klein
    • Mengyu Tu
    • Shiv K. Singh
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Human brain structure changes throughout the lifespan. Brouwer et al. identified genetic variants that affect rates of brain growth and atrophy. The genes are linked to early brain development and neurodegeneration and suggest involvement of metabolic processes.

    • Rachel M. Brouwer
    • Marieke Klein
    • Hilleke E. Hulshoff Pol
    Research
    Nature Neuroscience
    Volume: 25, P: 421-432

  • Studies of the physiological effects of metabolites often rely on injections of metabolite salts. In this study, Lund et al. show that the hypertonicity of the injected solutions can drive the metabolic effects attributed to pharmacological administration of lactate. This work highlights the importance of taking treatment osmolarity and counterions into account in the experimental design.

    • Jens Lund
    • Alberte Wollesen Breum
    • Christoffer Clemmensen
    Research
    Nature Metabolism
    Volume: 5, P: 677-698

  • Tools for neurophysiological monitoring in the marmoset are important for studies using this model. Here the authors perform multi-area neural recordings in awake behaving marmosets, and integrate with optogenetics and behaviour.

    • Patrick Jendritza
    • Frederike J. Klein
    • Pascal Fries
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16