Meliha Mehmeti et al. show that Wnt5a is a direct ligand of toll-like receptor 2 and 4 to act as an endogenous tolerance-associated molecular pattern, triggering innate immune tolerance in human myeloid cells. This study expands the functional repertoire of Wnt5a that is mainly known as a signalling protein involved in development and cancer.
- Meliha Mehmeti
- Caroline Bergenfelz
- Karin Leandersson
