The Ras GEF Ras-GRF2 is found to inhibit the activity of the Cdc42 Rho GTPase independently of its Ras-activating function. Binding of Ras-GRF2 to Cdc42 prevents its activation by Cdc42 GEFs suppressing Cdc42-mediated cell migration, invasion and transformation.
- Fernando Calvo
- Victoria Sanz-Moreno
- Piero Crespo