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Showing 1–3 of 3 results
Advanced filters: Author: Freya Klepsch Clear advanced filters

  • The folate pathway enzyme MTHFD1 is recruited to chromatin by BRD4. Inhibition of BRD4 or MTHFD1 similarly changes nuclear metabolite composition and gene expression, and dual inhibition synergistically impairs cancer cell viability.

    • Sara Sdelci
    • André F. Rendeiro
    • Stefan Kubicek
    Research
    Nature Genetics
    Volume: 51, P: 990-998

  • The use of a refined chemical library called the CeMM library of unique drugs (CLOUD) identified a synergistic interaction between flutamide and phenprocoumon in decreasing the growth of prostate cancer cells by regulating androgen receptor stability.

    • Marco P Licciardello
    • Anna Ringler
    • Stefan Kubicek
    Research
    Nature Chemical Biology
    Volume: 13, P: 771-778