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Showing 1–3 of 3 results

Advanced filters: Author: Friederike M. C. Benning Clear advanced filters

Treatment of a severe vascular disease using a bespoke CRISPR–Cas9 base editor in mice

Engineering a mutant-specific customized base editor precisely corrects a mutation while minimizing bystander edits, leading to substantial phenotypic recovery in mouse models of multisystemic smooth muscle dysfunction syndrome.

Christiano R. R. Alves
Sabyasachi Das
Patricia L. Musolino
Research11 Sept 2025
Nature Biomedical Engineering

P: 1-16
Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases

Click editing uses DNA polymerases, HUH endonucleases and oligonucleotide templates for genome modification.

Joana Ferreira da Silva
Connor J. Tou
Benjamin P. Kleinstiver
Research22 Jul 2024
Nature Biotechnology

Volume: 43, P: 923-935
Helical reconstruction of VP39 reveals principles for baculovirus nucleocapsid assembly

Baculoviruses are used as insecticides, gene therapy tools, and protein production vectors. Here, the authors report the structure of the Autographa californica MNPV nucleocapsid and its fold conservation across all baculoviruses.

Friederike M. C. Benning
Simon Jenni
Luke H. Chao
ResearchOpen Access04 Jan 2024
Nature Communications

Volume: 15, P: 1-14