Riemer et al. explore the relationship between early microstructural changes in subcortical volumes and development of depression in patients with relapsing-remitting Multiple Sclerosis (RRMS). Higher levels of free-water in the subcortical structures at an early stage of RRMS are associated with depression symptoms at a later stage of the disease.
- Frank Riemer
- Ellen Skorve
- Renate Grüner