Nature Search

Structural analysis reveals that water molecules mediate self-activation of GPR99

GPR99 self-activation is promoted by the second extracellular loop (ECL2) occupying the orthosteric pocket, which is stabilized by a water-mediated polar network. These findings provide a structural basis for this receptor’s physiological roles and a theoretical framework for designing drugs targeting the receptor.

Miaofang Xiao
Xiaoling Bao
Heng Liu
ResearchOpen Access30 Jan 2026
Communications Biology

P: 1-9
Molecular insights into ago-allosteric modulation at cysteinyl leukotriene receptor 2

Cysteinyl leukotriene receptor CysLT2R can be activated by cysteinyl leukotrienes LTC4, LTD4 and LTE4, and is associated with various inflammatory diseases. Here, authors present cryo-EM structures of CysLT2R-Gq bound to LTC4 and LTD4, which are characterized as ago-allosteric modulators of CysLT2R.

Mu Li
Xiaoling Bao
Heng Liu
ResearchOpen Access16 Dec 2025
Nature Communications

Volume: 17, P: 1-12
Comprehensive profiling of the catalytic conformations of human Guanylate kinase

Human guanylate kinase (GMPK) is the sole enzyme for GDP biosynthesis contributing to antiviral prodrug activation and tumorigenesis. Here, authors profile the ligand-specific conformations of human GMPK along with the reversible catalytic pathway.

Lei Wang
Zihuan Li
Ke Ruan
ResearchOpen Access25 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Bionic e-skin with precise multi-directional droplet sliding sensing for enhanced robotic perception

Electronic skins are limited in perceiving liquid sliding information as realistically as humans and provide real-time feedback. Here, Xu et al. developed a self-powered bionic droplet electronic skin with co-layer interlaced electrode networks and overpass connection technology to sense complex water motion.

Yunlong Xu
Zhongda Sun
Chengkuo Lee
ResearchOpen Access17 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Study on the dust distribution law in high chute mines based on grey relational analysis

Ming Wang
Ming Yang
Yixin Zhang
ResearchOpen Access31 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Identification of the Sex of Pre-implantation Mouse Embryos Using a Marked Y Chromosome and CRISPR/Cas9

Xiuling Zhao
Wei Wei
Ming Zhang
ResearchOpen Access04 Oct 2019
Scientific Reports

Volume: 9, P: 1-9
Long term prevention of disturbance induces the collapse of a dominant species without altering ecosystem function

Qiang Yu
Honghui Wu
Xingguo Han
ResearchOpen Access21 Sept 2015
Scientific Reports

Volume: 5, P: 1-9
Identification of causal plasma metabolite biomarkers for ischemic stroke using Mendelian randomization and mediation analysis

Jian Lyu
Fumei Liu
Yanming Xie
ResearchOpen Access14 May 2025
Scientific Reports

Volume: 15, P: 1-13
Serum metabolomics of hyperbilirubinemia and hyperuricemia in the Tibetan plateau has unique characteristics

Heng Zhang
Xianzong Ma
Jianqiu Sheng
ResearchOpen Access07 Aug 2023
Scientific Reports

Volume: 13, P: 1-12
Publisher Correction: Rapid differentiation of hiPSCs into functional oligodendrocytes using an OLIG2 synthetic modified messenger RNA

Jian Xu
Zhihua Yang
Yichu Nie
Amendments and CorrectionsOpen Access03 Nov 2022
Communications Biology

Volume: 5, P: 1
Rapid differentiation of hiPSCs into functional oligodendrocytes using an OLIG2 synthetic modified messenger RNA

The use of synthetic modified messenger RNA (smRNA) allows for the differentiation of human-induced pluripotent stem cells (hiPSCs) into lineage-specific oligodendrocytes.

Jian Xu
Zhihua Yang
Yichu Nie
ResearchOpen Access14 Oct 2022
Communications Biology

Volume: 5, P: 1-13
Initiating PeriCBD to probe perinatal influences on neurodevelopment during 3–10 years in China

Yin-Shan Wang
Xue-Ting Su
Xi-Nian Zuo
ResearchOpen Access07 May 2024
Scientific Data

Volume: 11, P: 1-17

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Structural analysis reveals that water molecules mediate self-activation of GPR99

Molecular insights into ago-allosteric modulation at cysteinyl leukotriene receptor 2

Comprehensive profiling of the catalytic conformations of human Guanylate kinase

Bionic e-skin with precise multi-directional droplet sliding sensing for enhanced robotic perception

Study on the dust distribution law in high chute mines based on grey relational analysis

Identification of the Sex of Pre-implantation Mouse Embryos Using a Marked Y Chromosome and CRISPR/Cas9

Long term prevention of disturbance induces the collapse of a dominant species without altering ecosystem function

Identification of causal plasma metabolite biomarkers for ischemic stroke using Mendelian randomization and mediation analysis

Serum metabolomics of hyperbilirubinemia and hyperuricemia in the Tibetan plateau has unique characteristics

Publisher Correction: Rapid differentiation of hiPSCs into functional oligodendrocytes using an OLIG2 synthetic modified messenger RNA

Rapid differentiation of hiPSCs into functional oligodendrocytes using an OLIG2 synthetic modified messenger RNA

Initiating PeriCBD to probe perinatal influences on neurodevelopment during 3–10 years in China

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