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Showing 1–3 of 3 results
Advanced filters: Author: Fumei Zhong Clear advanced filters

  • Cysteinyl leukotriene receptor CysLT2R can be activated by cysteinyl leukotrienes LTC4, LTD4 and LTE4, and is associated with various inflammatory diseases. Here, authors present cryo-EM structures of CysLT2R-Gq bound to LTC4 and LTD4, which are characterized as ago-allosteric modulators of CysLT2R.

    • Mu Li
    • Xiaoling Bao
    • Heng Liu
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-12

  • GPR99 self-activation is promoted by the second extracellular loop (ECL2) occupying the orthosteric pocket, which is stabilized by a water-mediated polar network. These findings provide a structural basis for this receptor’s physiological roles and a theoretical framework for designing drugs targeting the receptor.

    • Miaofang Xiao
    • Xiaoling Bao
    • Heng Liu
    ResearchOpen Access
    Communications Biology
    Volume: 9, P: 1-9

  • Human guanylate kinase (GMPK) is the sole enzyme for GDP biosynthesis contributing to antiviral prodrug activation and tumorigenesis. Here, authors profile the ligand-specific conformations of human GMPK along with the reversible catalytic pathway.

    • Lei Wang
    • Zihuan Li
    • Ke Ruan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12