Nature Search

Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity

Sawada et al. show simultaneous activation of the STING and lymphotoxin beta receptor signaling induces B cell-activating germinal center responses within tumor environment and enhances antitumor responses.

Junko Sawada
Yasuhiro Kikuchi
Masanobu Komatsu
ResearchOpen Access02 Sept 2025
Nature Immunology

Volume: 26, P: 1766-1780
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
In Vitro Antibacterial Activity of a New Cephalosporin, FR295389, against IMP-type Metallo-β-lactamase-producers

Shinobu Takeda
Fumiaki Ikeda
Kazuo Hatano
Research01 Jan 2008
The Journal of Antibiotics

Volume: 61, P: 36-39
Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages

The population genome structure of Asian Toxoplasma remains incompletely understood. This study analyzes intercontinental genomic admixture in 17 isolates from Japan and China, providing insights into the evolution of parasites and their impact on public health.

Fumiaki Ihara
Hisako Kyan
Masahiro Yamamoto
ResearchOpen Access22 May 2024
Nature Communications

Volume: 15, P: 1-17
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Evaluation of vascular pain in patients with colorectal cancer receiving peripheral venous chemotherapy with or without oxaliplatin

Taisuke Matsuoka
Yoichiro Yoshida
Suguru Hasegawa
ResearchOpen Access12 Feb 2019
Scientific Reports

Volume: 9, P: 1-6
5-Nitrouracil stabilizes the plasma concentration values of 5-FU in colorectal cancer patients receiving capecitabine

Yoichiro Yoshida
Yasuhiro Hashimoto
Suguru Hasegawa
ResearchOpen Access17 Feb 2020
Scientific Reports

Volume: 10, P: 1-7
Late-onset spastic ataxia phenotype in a patient with a homozygous DDHD2 mutation

Hiroshi Doi
Masao Ushiyama
Kunihiro Yoshida
ResearchOpen Access24 Nov 2014
Scientific Reports

Volume: 4, P: 1-7
Noninvasive spatiotemporal imaging of neural transmission in the subcortical visual pathway

Fumiaki Yoshida
Masayuki Hirata
Shiro Yorifuji
ResearchOpen Access30 Jun 2017
Scientific Reports

Volume: 7, P: 1-6
A microsensing system for the in vivo real-time detection of local drug kinetics

A system consisting of a glass microelectrode and a boron-doped diamond microsensor can simultaneously track, in rat brains and in the guinea pig cochlea, the local real-time kinetics of injected drugs and the resulting electrophysiological activity.

Genki Ogata
Yuya Ishii
Hiroshi Hibino
Research09 Aug 2017
Nature Biomedical Engineering

Volume: 1, P: 654-666
Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas

The EWS-ATF1 fusion gene causes clear cell sarcoma (CCS). Here, the authors show that the downstream effects of EWS-ATF1 expression are strictly context dependent, and reveal the cell of origin for CCS to be Tppp3-expressing cells in peripheral nerves.

Shingo Komura
Kenji Ito
Yasuhiro Yamada
ResearchOpen Access05 Sept 2019
Nature Communications

Volume: 10, P: 1-19
Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease

Long-read sequencing identifies a GGC repeat expansion in NOTCH2NLC that is associated with neuronal intranuclear inclusion disease, a progressive neurodegenerative disorder. The expansion results in abnormal anti-sense transcripts that could contribute to disease pathogenesis.

Jun Sone
Satomi Mitsuhashi
Gen Sobue
Research22 Jul 2019
Nature Genetics

Volume: 51, P: 1215-1221
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy

This study finds a direct correlation between LARGE-glycan extension on dystroglycan and the protein’s capacity for extracellular matrix ligands; in regenerating mouse muscle, short LARGE-glycan polysaccharides cause various defects, including muscle dysfunction and a predisposition to dystrophy, and in muscular dystrophy patients, increased clinical severity of disease corresponds to shorter LARGE-glycans.

Matthew M. Goddeeris
Biming Wu
Kevin P. Campbell
Research16 Oct 2013
Nature

Volume: 503, P: 136-140
Ets transcription factors cooperate with Sp1 to activate the human Tenascin-C promoter

Fumiaki Shirasaki
Huda A Makhluf
Maria Trojanowska
Research04 Jan 2000
Oncogene

Volume: 18, P: 7755-7764
Routine intracoronary imaging-guided left main coronary intervention

Yoshinobu Murasato
Hitoshi Nakashima
Hisako Yoshida
ResearchOpen Access19 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
Comparable outcomes with 14-, 21-, or standard 28-day venetoclax in the first cycle of azacitidine–venetoclax in untreated acute myeloid leukemia: real-world experience from the Hokkaido Leukemia Net

Minoru Kanaya
Masahiro Onozawa
Takanori Teshima
CorrespondenceOpen Access03 Jul 2025
Blood Cancer Journal

Volume: 15, P: 1-4
Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies

Improved expansion microscopy method preserves signal from fluorescent proteins and antibodies using off-the-shelf reagents.

Paul W Tillberg
Fei Chen
Edward S Boyden
Research04 Jul 2016
Nature Biotechnology

Volume: 34, P: 987-992
Soluble form of Lingo2, an autism spectrum disorder-associated molecule, functions as an excitatory synapse organizer in neurons

Fumiaki Yoshida
Ryota Nagatomo
Taisuke Tomita
ResearchOpen Access23 Oct 2024
Translational Psychiatry

Volume: 14, P: 1-12
Halistanol sulfates I and J, new SIRT1–3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria

Fumiaki Nakamura
Norio Kudo
Nobuhiro Fusetani
Research29 Nov 2017
The Journal of Antibiotics

Volume: 71, P: 273-278
Correction to: Halistanol sulfates I and J, new SIRT1–3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria

Fumiaki Nakamura
Norio Kudo
Nobuhiro Fusetani
Amendments and Corrections27 Mar 2018
The Journal of Antibiotics

Volume: 71, P: 483
Phase I/II clinical trial of nivolumab in combination with oligo-fractionated irradiation for unresectable advanced or recurrent gastric cancer

Mimura et al. report findings from a single arm, phase I/II study of combined radiation and anti-PD-1 therapy in patients with advanced or recurrent gastric cancer. Combination therapy achieves a disease control rate of 22.5% for non-irradiated lesions via an abscopal effect, or 40% for irradiated lesions, and a median survival time of 230 days.

Kosaku Mimura
Takashi Ogata
Koji Kono
ResearchOpen Access15 Aug 2023
Communications Medicine

Volume: 3, P: 1-7
Rapid and comprehensive diagnostic method for repeat expansion diseases using nanopore sequencing

Satoko Miyatake
Eriko Koshimizu
Naomichi Matsumoto
ResearchOpen Access26 Oct 2022
npj Genomic Medicine

Volume: 7, P: 1-15
MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP_L

Nakabayashi et al find that the E3 ligase MIB2 ubiquitylates the apoptosis-inhibitor cFLIP and that deletion of MIB2 enhances both RIPK1 kinase-dependent and -independent apoptosis through an increase in RIPK1 kinase activity and impairment of ubiquitylation of cFLIP_L, respectively.

Osamu Nakabayashi
Hirotaka Takahashi
Hiroyasu Nakano
ResearchOpen Access19 Jan 2021
Communications Biology

Volume: 4, P: 1-19
A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets

Watanabe et al. combine two previously developed strategies to identify E3 ubiquitin ligase substrates into a method, TR-TUBE that is subsequently used to identify substrates of the Parkin and TRIM28 ligases. They identify known substrates, validating the utility of the approach, and find that TRIM28 targets Cyclin A and TFIIB for degradation.

Masashi Watanabe
Yasushi Saeki
Shigetsugu Hatakeyama
ResearchOpen Access20 Oct 2020
Communications Biology

Volume: 3, P: 1-13
Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy

Yuki Yoshizaki
Takayasu Mori
Eisei Sohara
ResearchOpen Access21 Jun 2017
Scientific Reports

Volume: 7, P: 1-10
Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy

Shintaro Mandai
Susumu Furukawa
Shinichi Uchida
ResearchOpen Access18 Apr 2017
Scientific Reports

Volume: 7, P: 1-9
Non-invasive quantification of human swallowing using a simple motion tracking system

Hiroaki Hashimoto
Masayuki Hirata
Haruhiko Kishima
ResearchOpen Access23 Mar 2018
Scientific Reports

Volume: 8, P: 1-9
Computer modeling defines the system driving a constant current crucial for homeostasis in the mammalian cochlea by integrating unique ion transports

Fumiaki Nin
Takamasa Yoshida
Hiroshi Hibino
ResearchOpen Access25 Aug 2017
npj Systems Biology and Applications

Volume: 3, P: 1-10
Adding thiazide to a renin–angiotensin blocker improves left ventricular relaxation and improves heart failure in patients with hypertension

Hiroshi Ito
Katsuhisa Ishii
Junichi Yoshikawa
ResearchOpen Access20 Oct 2011
Hypertension Research

Volume: 35, P: 93-99
Hydroxyethyl cellulose matrix applied to serial crystallography

Michihiro Sugahara
Takanori Nakane
So Iwata
ResearchOpen Access06 Apr 2017
Scientific Reports

Volume: 7, P: 1-9
Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis

Kenichi Ishii
Fumiaki Tabuchi
Kazuhisa Sekimizu
ResearchOpen Access25 Nov 2015
Scientific Reports

Volume: 5, P: 1-10
Author Correction: Computer modeling defines the system driving a constant current crucial for homeostasis in the mammalian cochlea by integrating unique ion transports

Fumiaki Nin
Takamasa Yoshida
Hiroshi Hibino
Amendments and CorrectionsOpen Access18 Oct 2021
npj Systems Biology and Applications

Volume: 7, P: 1-2
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14

Search

Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity

Mapping the human genetic architecture of COVID-19

In Vitro Antibacterial Activity of a New Cephalosporin, FR295389, against IMP-type Metallo-β-lactamase-producers

Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages

A second update on mapping the human genetic architecture of COVID-19

Evaluation of vascular pain in patients with colorectal cancer receiving peripheral venous chemotherapy with or without oxaliplatin

5-Nitrouracil stabilizes the plasma concentration values of 5-FU in colorectal cancer patients receiving capecitabine

Late-onset spastic ataxia phenotype in a patient with a homozygous DDHD2 mutation

Noninvasive spatiotemporal imaging of neural transmission in the subcortical visual pathway

A microsensing system for the in vivo real-time detection of local drug kinetics

Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas

Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy

Ets transcription factors cooperate with Sp1 to activate the human Tenascin-C promoter

Routine intracoronary imaging-guided left main coronary intervention

Comparable outcomes with 14-, 21-, or standard 28-day venetoclax in the first cycle of azacitidine–venetoclax in untreated acute myeloid leukemia: real-world experience from the Hokkaido Leukemia Net

Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies

Soluble form of Lingo2, an autism spectrum disorder-associated molecule, functions as an excitatory synapse organizer in neurons

Halistanol sulfates I and J, new SIRT1–3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria

Correction to: Halistanol sulfates I and J, new SIRT1–3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria

Phase I/II clinical trial of nivolumab in combination with oligo-fractionated irradiation for unresectable advanced or recurrent gastric cancer

Rapid and comprehensive diagnostic method for repeat expansion diseases using nanopore sequencing

MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP_L

A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets

Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy

Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy

Non-invasive quantification of human swallowing using a simple motion tracking system

Computer modeling defines the system driving a constant current crucial for homeostasis in the mammalian cochlea by integrating unique ion transports

Adding thiazide to a renin–angiotensin blocker improves left ventricular relaxation and improves heart failure in patients with hypertension

Hydroxyethyl cellulose matrix applied to serial crystallography

Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis

Author Correction: Computer modeling defines the system driving a constant current crucial for homeostasis in the mammalian cochlea by integrating unique ion transports

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

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