Designer enzymes comprising an abiological molecule incorporated into a natural protein have been reported, but the use of proteins as ligands to construct abiological (multinuclear) metal centers is rare. Here, the authors report a designer multi-metalloenzyme with extrinsic and intrinsic functions obtained by grafting a synthetic trinuclear zinc complex inside a human cytokine macrophage migration inhibitory factor scaffold.
- Akiko Ueno
- Fumiko Takida
- Yasunori Okamoto
