Nature Search

Lerociclib plus fulvestrant in patients with HR+/HER2− locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomized trial

CDK4/6 inhibition is often effective for those with breast cancer but success is limited by adverse reactions. Here, the authors report a phase III randomised trial comparing fulvestrant (oestrogen receptor antagonist) with or without lerociclib (CDK4/6 inhibitor) for the treatment of hormone receptor-positive HER2-negative, endocrine-resistant advanced breast cancer.

Binghe Xu
Qingyuan Zhang
Tong Li
ResearchOpen Access16 Jan 2025
Nature Communications

Volume: 16, P: 1-9
A mutant-cell library for systematic analysis of heparan sulfate structure–function relationships

A library of mutant mouse lung endothelial cells expressing a comprehensive repertoire of heparin sulfate structure modifications enables studies of the structure–function relationships of this complex polysaccharide.

Hong Qiu
Songshan Shi
Lianchun Wang
Research30 Oct 2018
Nature Methods

Volume: 15, P: 889-899
Two vs three cycles of neoadjuvant sintilimab plus chemotherapy for resectable non-small-cell lung cancer: neoSCORE trial

Miner Shao
Jie Yao
Fuming Qiu
ResearchOpen Access10 Apr 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-3
Tumor-derived HMGB1 induces CD62L^dim neutrophil polarization and promotes lung metastasis in triple-negative breast cancer

Zhen Wang
Chenghui Yang
Jian Huang
ResearchOpen Access17 Sept 2020
Oncogenesis

Volume: 9, P: 1-17
Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma

Chenguang Li
Zhibo Gao
Qingyi Wei
ResearchOpen Access27 Oct 2015
Scientific Reports

Volume: 5, P: 1-11
Human γδT-cell subsets and their involvement in tumor immunity

Dang Wu
Pin Wu
Jian Huang
ReviewsOpen Access28 Nov 2016
Cellular & Molecular Immunology

Volume: 14, P: 245-253

Quick links

Search

Filter By:

Lerociclib plus fulvestrant in patients with HR+/HER2− locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomized trial

A mutant-cell library for systematic analysis of heparan sulfate structure–function relationships

Two vs three cycles of neoadjuvant sintilimab plus chemotherapy for resectable non-small-cell lung cancer: neoSCORE trial

Tumor-derived HMGB1 induces CD62Ldim neutrophil polarization and promotes lung metastasis in triple-negative breast cancer

Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma

Human γδT-cell subsets and their involvement in tumor immunity

Search

Quick links

Tumor-derived HMGB1 induces CD62L^dim neutrophil polarization and promotes lung metastasis in triple-negative breast cancer