Nature Search

In vivo electrochemical reduction-induced reconfiguration of Prussian blue for metal counterion-free potassium removal in hyperkalemia

Researchers repurpose Prussian Blue and Vitamin C to treat dangerously high potassium levels in mice. This approach safely traps potassium without releasing harmful sodium, offering an potential option for heart and kidney patients.

Yuge Wu
Liang Xiang
Shiyi Zhang
ResearchOpen Access23 Dec 2025
Nature Communications

Volume: 17, P: 1-13
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

A genetic study identifies hundreds of loci associated with risk tolerance and risky behaviors, finds evidence of substantial shared genetic influences across these phenotypes, and implicates genes involved in neurotransmission.

Richard Karlsson Linnér
Pietro Biroli
Jonathan P. Beauchamp
Research14 Jan 2019
Nature Genetics

Volume: 51, P: 245-257
Development and application of new composite grouting material for sealing groundwater inflow and reinforcing wall rock in deep mine

Zhang Jinpeng
Liu Limin
Cao Junzhi
ResearchOpen Access04 Apr 2018
Scientific Reports

Volume: 8, P: 1-11
Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease

Parkinson’s disease (PD) is a common neurodegenerative disorder with a complex etiology involving genetics and the environment. Here, Vallerga et al. identify two CpG probes associated with PD in a blood cell type-corrected epigenome-wide meta-analysis, implicating the SLC7A11 gene as a plausible biological target.

Costanza L. Vallerga
Futao Zhang
Jacob Gratten
ResearchOpen Access06 Mar 2020
Nature Communications

Volume: 11, P: 1-10
Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

The identification of the causal gene at a GWAS locus remains to be a challenging task. Here, using the SMR & HEIDI method to integrate GWAS, eQTL and mQTL data, Wu et al. map DNA methylation sites to the transcriptome and thereby prioritize functionally relevant genes for 12 human complex traits.

Yang Wu
Jian Zeng
Jian Yang
ResearchOpen Access02 Mar 2018
Nature Communications

Volume: 9, P: 1-14
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent risk loci. Comparisons with other psychiatric disorders and candidate gene analyses provide new insights into major depressive disorder.

Naomi R. Wray
Stephan Ripke
Patrick F. Sullivan
Research26 Apr 2018
Nature Genetics

Volume: 50, P: 668-681
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Analyses of expression profiles from whole blood of 31,684 individuals identify cis-expression quantitative trait loci (eQTL) effects for 88% of genes and trans-eQTL effects for 37% of trait-associated variants.

Urmo Võsa
Annique Claringbould
Lude Franke
Research02 Sept 2021
Nature Genetics

Volume: 53, P: 1300-1310
Glans penis electric stimulation modulates cerebral activity and functional connectivity in lifelong premature ejaculation revealed by functional MRI

Yijun Bai
Futao Chen
Bing Zhang
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

Promoter-anchored chromatin interaction (PAI) is a mechanism by which gene expression is regulated, but methods to measure PAIs are costly and currently not scalable. Here, the authors develop an approach by which PAIs can be predicted using summary-level data from methylation QTL studies.

Yang Wu
Ting Qi
Jian Yang
ResearchOpen Access28 Apr 2020
Nature Communications

Volume: 11, P: 1-12
Genetic control of RNA splicing and its distinct role in complex trait variation

A powerful method for splicing quantitative trait loci (sQTL) mapping, THISTLE, is presented and applied to a collection of 2,865 brain samples. Integration with GWAS identifies 244 genes associated via cis-sQTLs, of which 61% were not identified using expression QTLs.

Ting Qi
Yang Wu
Jian Yang
ResearchOpen Access18 Aug 2022
Nature Genetics

Volume: 54, P: 1355-1363
Two-dimensional semiconductor integrated circuits operating at gigahertz frequencies

Five-stage ring oscillators that operate at frequencies of up to 2.65 GHz can be created using monolayer molybdenum disulfide field-effect transistors developed with a design-technology co-optimization process.

Dongxu Fan
Weisheng Li
Xinran Wang
Research26 Oct 2023
Nature Electronics

Volume: 6, P: 879-887
Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

To comprehend the genetic regulatory mechanisms underlying brain-related traits in humans, Qi et al. estimate the correlation of expression and DNA methylation QTL effects in cis between blood and brain and show that using blood eQTL/mQTL data of large sample size can increase power in gene discovery for brain-related traits and diseases.

Ting Qi
Yang Wu
Jian Yang
ResearchOpen Access11 Jun 2018
Nature Communications

Volume: 9, P: 1-12
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

GWAS have so far identified 129 loci associated with type 2 diabetes (T2D). Here, the authors meta-analyse three large T2D GWA studies which uncovers 42 additional loci, further prioritize 33 functional genes using eQTL and mQTL data and propose regulatory mechanisms for three putative T2D genes.

Angli Xue
Yang Wu
Jian Yang
ResearchOpen Access27 Jul 2018
Nature Communications

Volume: 9, P: 1-14
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism

Endometriosis is a major cause of infertility. Molecular mechanisms underlying the disease involve genetic and environmental risk factors. In a meta-analysis of eleven GWA studies, Sapkota and colleagues identify five novel risk loci, implicating steroid sex hormone pathways in the pathogenesis.

Yadav Sapkota
Valgerdur Steinthorsdottir
Dale R. Nyholt
ResearchOpen Access24 May 2017
Nature Communications

Volume: 8, P: 1-12
Causal associations between risk factors and common diseases inferred from GWAS summary data

Genetic methods are useful to test whether risk factors are causal for or consequence of disease. Here, Zhu et al. develop a generalized summary-based Mendelian Randomization (GSMR) method which uses summary-level data from GWAS to test for causal associations of health risk factors with common diseases.

Zhihong Zhu
Zhili Zheng
Jian Yang
ResearchOpen Access15 Jan 2018
Nature Communications

Volume: 9, P: 1-12
Exploring the relationship between childhood maltreatment and cognitive bias in Chinese adults with major depressive disorder

Jintao Xiong
Mengqi Xu
Lingjiang Li
ResearchOpen Access27 Mar 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-9
An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins

The discovery of two new types of enzymes that act in tandem within the spirotetramate biosynthetic pathway to catalyze [4+2] cycloadditions offers new opportunities for mechanistic investigations of potential Diels-Alderases.

Zhenhua Tian
Peng Sun
Wen Liu
Research02 Mar 2015
Nature Chemical Biology

Volume: 11, P: 259-265
OTTERS: a powerful TWAS framework leveraging summary-level reference data

Here, the authors present a TWAS framework OTTERS that adapts multiple polygenic risk score methods to estimate eQTL weights from summary-level eQTL data. Both simulation and real studies show OTTERS is powerful across a wide range of genetic architectures.

Qile Dai
Geyu Zhou
Jingjing Yang
ResearchOpen Access07 Mar 2023
Nature Communications

Volume: 14, P: 1-13
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

This genome-wide study of age at first sexual intercourse and first birth identifies 371 signals driven by reproductive biology, externalising behaviour and environmental effects, with later onset associated with lower incidence of some diseases.

Melinda C. Mills
Felix C. Tropf
Felix R. Day
Research01 Jul 2021
Nature Human Behaviour

Volume: 5, P: 1717-1730
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.

Xueyi Shen
David M. Howard
Andrew M. McIntosh
ResearchOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1-16
Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

Many genetic variants identified in genome-wide association studies are associated with gene expression. Here, Porcu et al. propose a transcriptome-wide summary statistics-based Mendelian randomization approach (TWMR) that, applied to 43 human traits, uncovers hundreds of previously unreported gene–trait associations.

Eleonora Porcu
Sina Rüeger
Zoltán Kutalik
ResearchOpen Access24 Jul 2019
Nature Communications

Volume: 10, P: 1-12
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Environmental influences during prenatal development may have implications for health and disease later in life. Here, Czamara et al. assess DNA methylation in cord blood from new-born under various models including environmental and genetic effects individually and their additive or interaction effects.

Darina Czamara
Gökçen Eraslan
Elisabeth B. Binder
ResearchOpen Access11 Jun 2019
Nature Communications

Volume: 10, P: 1-18
Identification of common genetic risk variants for autism spectrum disorder

A genome-wide-association meta-analysis of 18,381 austim spectrum disorder (ASD) cases and 27,969 controls identifies five risk loci. The authors find quantitative and qualitative polygenic heterogeneity across ASD subtypes.

Jakob Grove
Stephan Ripke
Anders D. Børglum
Research25 Feb 2019
Nature Genetics

Volume: 51, P: 431-444
Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis

Marta F. Nabais
Tian Lin
Naomi R. Wray
ResearchOpen Access27 Feb 2020
npj Genomic Medicine

Volume: 5, P: 1-9
Targeting TLK2 inhibits the progression of gastric cancer by reprogramming amino acid metabolism through the mTOR/ASNS axis

Mingliang Wang
Jing Li
Yongxiang Li
Research04 Aug 2023
Cancer Gene Therapy

Volume: 30, P: 1485-1497
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

Jian Yang and colleagues propose a method that integrates summary data from GWAS and eQTL studies to identify genes whose expression levels are associated with complex traits because of pleiotropy. They apply the method to five human complex traits and prioritize 126 genes for future functional studies.

Zhihong Zhu
Futao Zhang
Jian Yang
Research28 Mar 2016
Nature Genetics

Volume: 48, P: 481-487
The neuroprogressive nature of major depressive disorder: evidence from an intrinsic connectome analysis

Jin Liu
Yiming Fan
Lingjiang Li
ResearchOpen Access04 Feb 2021
Translational Psychiatry

Volume: 11, P: 1-11
Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability

Regina H. Reynolds
Juan Botía
Mina Ryten
ResearchOpen Access17 Apr 2019
npj Parkinson's Disease

Volume: 5, P: 1-14
Effects of early feeding on the host rumen transcriptome and bacterial diversity in lambs

Weimin Wang
Chong Li
Baosheng Li
ResearchOpen Access31 Aug 2016
Scientific Reports

Volume: 6, P: 1-14
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Research23 Jan 2020
Molecular Psychiatry

Volume: 25, P: 1430-1446
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Azmeraw T. Amare
Klaus Oliver Schubert
Bernhard T. Baune
Research16 Mar 2020
Molecular Psychiatry

Volume: 26, P: 2457-2470
Publisher Correction: Identification of 371 genetic variants for age at first sex and birth linked to externalising behavior

Melinda C. Mills
Felix C. Tropf
Felix R. Day
Amendments and Corrections28 Jul 2021
Nature Human Behaviour

Volume: 5, P: 1111
Association of residual feed intake with growth and slaughtering performance, blood metabolism, and body composition in growing lambs

Xiaoxue Zhang
Weimin Wang
Fadi Li
ResearchOpen Access04 Oct 2017
Scientific Reports

Volume: 7, P: 1-11
New insights into follicular helper T cell response and regulation in autoimmune pathogenesis

Fan Xiao
Man Han
Liwei Lu
Comments & Opinion10 May 2021
Cellular & Molecular Immunology

Volume: 18, P: 1610-1612
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Simone de Jong et al. examine the balance of common and rare risk for psychiatric disorders in a large family with high incidence of Bipolar Disorder and Major Depressive Disorder. They find that increased polygenic risk over generations could be partially due to assortative mating, which may explain the observation of anticipation in mood disorders.

Simone de Jong
Mateus Jose Abdalla Diniz
Gerome Breen
ResearchOpen Access08 Oct 2018
Communications Biology

Volume: 1, P: 1-10
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Till F. M. Andlauer
Jose Guzman-Parra
Marcella Rietschel
ResearchOpen Access11 Nov 2019
Molecular Psychiatry

Volume: 26, P: 1286-1298
Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Amendments and Corrections18 May 2020
Molecular Psychiatry

Volume: 26, P: 5465

Search

In vivo electrochemical reduction-induced reconfiguration of Prussian blue for metal counterion-free potassium removal in hyperkalemia

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Development and application of new composite grouting material for sealing groundwater inflow and reinforcing wall rock in deep mine

Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease

Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Glans penis electric stimulation modulates cerebral activity and functional connectivity in lifelong premature ejaculation revealed by functional MRI

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

Genetic control of RNA splicing and its distinct role in complex trait variation

Two-dimensional semiconductor integrated circuits operating at gigahertz frequencies

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism

Causal associations between risk factors and common diseases inferred from GWAS summary data

Exploring the relationship between childhood maltreatment and cognitive bias in Chinese adults with major depressive disorder

An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins

OTTERS: a powerful TWAS framework leveraging summary-level reference data

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Identification of common genetic risk variants for autism spectrum disorder

Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis

Targeting TLK2 inhibits the progression of gastric cancer by reprogramming amino acid metabolism through the mTOR/ASNS axis

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

The neuroprogressive nature of major depressive disorder: evidence from an intrinsic connectome analysis

Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability

Effects of early feeding on the host rumen transcriptome and bacterial diversity in lambs

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Publisher Correction: Identification of 371 genetic variants for age at first sex and birth linked to externalising behavior

Association of residual feed intake with growth and slaughtering performance, blood metabolism, and body composition in growing lambs

New insights into follicular helper T cell response and regulation in autoimmune pathogenesis

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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