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Showing 1–7 of 7 results
Advanced filters: Author: Fynn M. Hansen Clear advanced filters

  • Multi-omics profiling of effects of SARS-CoV-2 and SARS-CoV on A549, a lung-derived human cell line, produces a dataset enabling identification of common and virus-specific mechanisms of infection.

    • Alexey Stukalov
    • Virginie Girault
    • Andreas Pichlmair
    Research
    Nature
    Volume: 594, P: 246-252

  • Using synthetic ubiquitins with non-natural acceptor site, the authors revealed that the length of lysine side chain in acceptor ubiquitins affects ubiquitin chain linkage specificity with native lysine as the preferred geometry.

    • Joanna Liwocha
    • David T. Krist
    • Brenda A. Schulman
    Research
    Nature Chemical Biology
    Volume: 17, P: 272-279

  • Protein ubiquitylation is often studied by proteomics but how data independent acquisition (DIA) may advance these studies remains to be explored. Here, the authors show that DIA improves ubiquitylation site identification and quantification, enabling them to characterize the circadian ubiquitinome in human cells.

    • Fynn M. Hansen
    • Maria C. Tanzer
    • Matthias Mann
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29