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Cell Death & Disease (15)
Cell Death and Differentiation (7)
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Showing 1–26 of 26 results

Advanced filters: Author: G Dewson Clear advanced filters

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

A phenotypic screen led to the identification of potent inhibitors of mouse BAK-driven apoptosis. The compounds interact with VDAC2 and stabilize its interaction with BAK, blocking apoptosis at an early stage to preserve long-term cell survival.

Mark F. van Delft
Stephane Chappaz
Benjamin T. Kile
Research07 Oct 2019
Nature Chemical Biology

Volume: 15, P: 1057-1066
Mitochondria and cell death

Several processes of regulated cell death engage or use mitochondria, which are thus central hubs that not only coordinate cell death but also elicit non-lethal signalling mediated by mitochondrial outer membrane permeabilization.

Hannah L. Glover
Annabell Schreiner
Stephen W. G. Tait
Reviews20 Jun 2024
Nature Cell Biology

Volume: 26, P: 1434-1446
Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

S Iyer
F Bell
R M Kluck
Research06 Mar 2015
Cell Death & Differentiation

Volume: 22, P: 1665-1675
Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells

A Weber
Z Kirejczyk
G Häcker
Research18 Dec 2009
Cell Death & Differentiation

Volume: 17, P: 942-951
Peripheral immune cell abundance differences link blood mitochondrial DNA copy number and Parkinson’s disease

Longfei Wang
Jiru Han
Melanie Bahlo
ResearchOpen Access14 Nov 2024
npj Parkinson's Disease

Volume: 10, P: 1-10
Bak apoptotic function is not directly regulated by phosphorylation

V H Tran
R Bartolo
R M Kluck
ResearchOpen Access10 Jan 2013
Cell Death & Disease

Volume: 4, P: e452
Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

S B Ma
T N Nguyen
G Dewson
Research22 Aug 2014
Cell Death & Differentiation

Volume: 21, P: 1925-1935
MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells

Nabanita Mukherjee
Jenette Skees
Yiqun G. Shellman
ResearchOpen Access08 Jun 2020
Cell Death & Disease

Volume: 11, P: 1-14
ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis

J J Sandow
L Dorstyn
P G Ekert
Research29 Nov 2013
Cell Death & Differentiation

Volume: 21, P: 475-480
Endothelial cell survival during angiogenesis requires the pro-survival protein MCL1

E C Watson
L Whitehead
L Coultas
Research04 Mar 2016
Cell Death & Differentiation

Volume: 23, P: 1371-1379
Bax dimerizes via a symmetric BH3:groove interface during apoptosis

G Dewson
S Ma
R M Kluck
Research21 Oct 2011
Cell Death & Differentiation

Volume: 19, P: 661-670
Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax

C Hockings
K Anwari
R M Kluck
ResearchOpen Access23 Apr 2015
Cell Death & Disease

Volume: 6, P: e1735
Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis

D Westphal
R M Kluck
G Dewson
Reviews25 Oct 2013
Cell Death & Differentiation

Volume: 21, P: 196-205
Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737

V R Sutton
K Sedelies
N J Waterhouse
ResearchOpen Access05 Jul 2012
Cell Death & Disease

Volume: 3, P: e344
Parkin and mitophagy in cancer

J P Bernardini
M Lazarou
G Dewson
Reviews05 Sept 2016
Oncogene

Volume: 36, P: 1315-1327
Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction

A Y Robin
K Krishna Kumar
P E Czabotar
ResearchOpen Access09 Jul 2015
Cell Death & Disease

Volume: 6, P: e1809
Cellular oxidative stress response mediates radiosensitivity in Fus1-deficient mice

E M Yazlovitskaya
P A Voziyan
A V Ivanova
ResearchOpen Access19 Feb 2015
Cell Death & Disease

Volume: 6, P: e1652
ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts

M N Washington
G Suh
Z Lu
ResearchOpen Access06 Aug 2015
Cell Death & Disease

Volume: 6, P: e1836
Role of non-genomic androgen signalling in suppressing proliferation of fibroblasts and fibrosarcoma cells

G Castoria
P Giovannelli
A Migliaccio
ResearchOpen Access04 Dec 2014
Cell Death & Disease

Volume: 5, P: e1548
Photoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition

P Nowak-Sliwinska
A Weiss
A W Griffioen
ResearchOpen Access12 Feb 2015
Cell Death & Disease

Volume: 6, P: e1641
Intracellular annexin A2 regulates NF-κB signaling by binding to the p50 subunit: implications for gemcitabine resistance in pancreatic cancer

H Jung
J S Kim
K-H Bae
ResearchOpen Access22 Jan 2015
Cell Death & Disease

Volume: 6, P: e1606
cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities

S Bleicken
G Hofhaus
A J García-Sáez
ResearchOpen Access25 Feb 2016
Cell Death & Disease

Volume: 7, P: e2121
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

J D Leverson
H Zhang
A J Souers
ResearchOpen Access15 Jan 2015
Cell Death & Disease

Volume: 6, P: e1590
HOI-02 induces apoptosis and G2-M arrest in esophageal cancer mediated by ROS

C Zhang
K Liu
Z Dong
ResearchOpen Access15 Oct 2015
Cell Death & Disease

Volume: 6, P: e1912
Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain

J-S Kim
B Ku
N-C Ha
ResearchOpen Access02 Jul 2015
Cell Death & Disease

Volume: 6, P: e1804
Synergistic anti-tumor activity and inhibition of angiogenesis by cotargeting of oncogenic and death receptor pathways in human melanoma

G Grazia
C Vegetti
A Anichini
ResearchOpen Access02 Oct 2014
Cell Death & Disease

Volume: 5, P: e1434