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Showing 1–9 of 9 results
Advanced filters: Author: G. Almouzni Clear advanced filters

  • In mammals, two major non-centromeric histone H3 (H3.1/2 and H3.3) variants, display distinct nuclear distribution patterns across the genome and use distinct deposition pathways. Here the authors reveal insights on the nuclear distribution of H3.1 and H3.3 variants, focusing on their relative enrichment at chromocenters throughout the cell cycle and in different cellular states.

    • S. Arfè
    • T. Karagyozova
    • G. Almouzni
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • A package of papers investigates the functional regulatory elements in genomes that have been obtained from human tissue samples and cell lines. The implications of the project are presented here from three viewpoints. See Articles p.317, p.331, p.337 & p.344 and Letters p.350, p.355, p.360 & p.365

    • Casey E. Romanoski
    • Christopher K. Glass
    • Genevieve Almouzni
    News & Views
    Nature
    Volume: 518, P: 314-316

  • The LifeTime initiative is an ambitious, multidisciplinary programme that aims to improve healthcare by tracking individual human cells during disease processes and responses to treatment in order to develop and implement cell-based interceptive medicine in Europe.

    • Nikolaus Rajewsky
    • Geneviève Almouzni
    • Frauke Zipp
    Reviews
    Nature
    Volume: 587, P: 377-386

  • A plan to 'genomicize' epigenomics research and pave the way for breakthroughs in the prevention, diagnosis and treatment of human disease.

    • Peter A. Jones
    • Trevor K. Archer
    • Carl Wu
    Special Features
    Nature
    Volume: 454, P: 711-715

  • Cell fate commitment involves transcription factor activity and changes in chromatin architecture. Here the authors show that CAF-1 maintains lineage fidelity by controlling chromatin accessibility at specific sites; suppressing CAF-1 triggers differentiation of myeloid stem and progenitor cells into a mixed lineage state.

    • Reuben Franklin
    • Yiming Guo
    • Sihem Cheloufi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • A scalable approach to explore DNA replication in single cells reveals that although aneuploidy does not have a major impact on the pattern of replication, different cell types and sub-populations display distinguished replication paths.

    • Stefano Gnan
    • Joseph M. Josephides
    • Chun-Long Chen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • During the cell cycle, the centromeres of chromosomes have important roles and face key challenges, such as mediating successful chromosome segregation during mitosis and faithfully propagating their chromatin state to daughter chromosomes during S phase. This Review describes cell cycle-related features of centromeres, focusing on the nature and dynamics of centromeric chromatin, how it is intricately regulated and the potential implications for disease when these processes are disrupted.

    • Sebastian Müller
    • Geneviève Almouzni
    Reviews
    Nature Reviews Genetics
    Volume: 18, P: 192-208