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Development of a targeted BioPROTAC degrader selective for misfolded SOD1

Conventional PROTACs have limited capacity for misfolded proteins. Here, authors develop a BioPROTAC containing an scFv specifically targeting misfolded SOD1, fused to an E3 ligase, and demonstrate a strategy for reducing misfolded SOD1 accumulation.

Christen G. Chisholm
Rachael Bartlett
Justin J. Yerbury
ResearchOpen Access10 Nov 2025
Nature Communications

Volume: 16, P: 1-16
Mutagenic effect of aromatic epoxy resins

G. C. GRANVILLE
Research24 May 1979
Nature

Volume: 279, P: 352
Lactose Intolerance in Thailand

G. FLATZ
CH. SAENGUDOM
T. SANGUANBHOKHAI
Research22 Feb 1969
Nature

Volume: 221, P: 758-759
Bcl-2 overexpression blocks caspase activation and downstream apoptotic events instigated by photodynamic therapy

D J Granville
H Jiang
D W C Hunt
ResearchOpen Access11 Dec 1998
British Journal of Cancer

Volume: 79, P: 95-100
Photodynamic therapy induces caspase-3 activation in HL-60 cells

David J Granville
Julia G Levy
David WC Hunt
Research01 Oct 1997
Cell Death & Differentiation

Volume: 4, P: 623-628
Toward a synthesis of Paleoamerican fluted point cultures in the Carolinas

I. Randolph Daniel Jr.
Albert C. Goodyear
Joseph E. Wilkinson
ResearchOpen Access04 Aug 2025
Scientific Reports

Volume: 15, P: 1-30
Alarm Pheromone and Avoidance Conditioning in Goldfish, Carassius auratus

G. McA. KIMBRELL
MARK R. WEINROTT
DEBORAH SANGSTON
Research21 Feb 1970
Nature

Volume: 225, P: 754
The Elephant Trench at Dewlish”Was it Dug?

G. W. B. MACTURK
Research09 Oct 1913
Nature

Volume: 92, P: 166
Designation of Heavy Hydrogen

HAROLD C. UREY
F. G. BRICKWEDDE
G. M. MURPHY
Research03 Feb 1934
Nature

Volume: 133, P: 173
Fusion Of Uredospore Germ Tubes in Puccinia graminis

J. G. MANNERS
S. S. BAMPTON
Research02 Mar 1957
Nature

Volume: 179, P: 483-484
General the Hon. C. G. Bruce, C.B.

T. G. LONGSTAFF
News02 Sept 1939
Nature

Volume: 144, P: 407
Do graded units of accretionary spheroids in the Barberton Greenstone Belt indicate Archaean deep water environment?

Ian G. Stanistreet
Maarten J. de Wit
Rodney E. P. Fripp
Research24 Sept 1981
Nature

Volume: 293, P: 280-284
Thresholds for adding degraded tropical forest to the conservation estate

An analysis of the impact of logging intensity on biodiversity in tropical forests in Sabah, Malaysia, identifies a threshold of tree biomass removal below which logged forests still have conservation value.

Robert M. Ewers
C. David L. Orme
Cristina Banks-Leite
ResearchOpen Access17 Jul 2024
Nature

Volume: 631, P: 808-813
Serum Lipids and the Death of Spawning Pacific Salmon

STUART PATTON
G. F. CROZIER
A. A. BENSON
Research21 Feb 1970
Nature

Volume: 225, P: 754-755
Dimethyl Myleran Therapy Combined with Abdominal Aortic Occlusion

Peter Clifford
R A Clift
G M Timmis
Research01 Sept 1964
British Journal of Cancer

Volume: 18, P: 435-448
A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

Matrix metalloproteinases (MMPs) normally act extracellularly. Now Marchant et al. report an unexpected nuclear activity for MMP-12 in virus-infected cells in regulating transcription of the gene encoding IκBα and affecting secretion of interferon-α.

David J Marchant
Caroline L Bellac
Christopher M Overall
Research28 Apr 2014
Nature Medicine

Volume: 20, P: 493-502
Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors

GPR88 is an orphan G protein–coupled receptor expressed in striatal medium spiny neurons (MSNs). The authors show that deletion of Gpr88 in mice leads to hyperactivity, poor motor coordination and impaired cue-based learning. MSNs lacking GPR88 show increased excitation and reduced inhibition in vitro, and enhanced firing rates in vivo.

Albert Quintana
Elisenda Sanz
Richard D Palmiter
Research14 Oct 2012
Nature Neuroscience

Volume: 15, P: 1547-1555
Potentiation of the anti-tumour effects of Photofrin®-based photodynamic therapy by localized treatment with G-CSF

J Goląb
G Wilczyński
M Jakóbisiak
ResearchOpen Access21 Mar 2000
British Journal of Cancer

Volume: 82, P: 1485-1491
Nucleation and annihilation of skyrmions in Mn₂CoAl observed through the topological Hall effect

B. M. Ludbrook
G. Dubuis
S. Granville
ResearchOpen Access19 Oct 2017
Scientific Reports

Volume: 7, P: 1-8
The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition

M Shiono
T Kobayashi
O Hino
Research11 Aug 2008
Oncogene

Volume: 27, P: 6690-6697
Heme oxygenase-1 protects tumor cells against photodynamic therapy-mediated cytotoxicity

D Nowis
M Legat
J Gołab
Research06 Feb 2006
Oncogene

Volume: 25, P: 3365-3374
The helper T lymphocyte precursor (HTLp) frequency does not predict outcome after HLA-identical sibling donor G-CSF-mobilised peripheral blood stem cell transplantation

G Healey
AP Schwarer
Research17 Sept 2002
Bone Marrow Transplantation

Volume: 30, P: 341-346
Epithelial nuclear factor-κB signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes

R Zaynagetdinov
G T Stathopoulos
T S Blackwell
Research17 Oct 2011
Oncogene

Volume: 31, P: 3164-3176
Prediction of human population responses to toxic compounds by a collaborative competition

Crowdsourcing analysis improves computational prediction of cytotoxic responses in humans.

Federica Eduati
Lara M Mangravite
Julio Saez-Rodriguez
ResearchOpen Access01 Sept 2015
Nature Biotechnology

Volume: 33, P: 933-940
Distinct alterations in probabilistic reversal learning across at-risk mental state, first episode psychosis and persistent schizophrenia

J. D. Griffin
K. M. J. Diederen
P. C. Fletcher
ResearchOpen Access30 Jul 2024
Scientific Reports

Volume: 14, P: 1-18
Improved detection of clinically significant host-reactive antigens prior to HLA-identical sibling peripheral blood stem cell transplantation using a dendritic cell-based helper T-lymphocyte precursor assay

A P Schwarer
G Healey
M Hammett
Research12 Jan 2004
Bone Marrow Transplantation

Volume: 33, P: 367-375
Serpina3n accelerates tissue repair in a diabetic mouse model of delayed wound healing

I Hsu
L G Parkinson
D J Granville
ResearchOpen Access09 Oct 2014
Cell Death & Disease

Volume: 5, P: e1458
Lithium suppression of tau induces brain iron accumulation and neurodegeneration

P Lei
S Ayton
A I Bush
Research12 Jul 2016
Molecular Psychiatry

Volume: 22, P: 396-406
Corals regulate the distribution and abundance of Symbiodiniaceae and biomolecules in response to changing water depth and sea surface temperature

Mayandi Sivaguru
Lauren G. Todorov
Bruce W. Fouke
ResearchOpen Access26 Jan 2021
Scientific Reports

Volume: 11, P: 1-19
Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes

P J Hanson
X Ye
D Yang
Research20 Nov 2015
Cell Death & Differentiation

Volume: 23, P: 828-840
Direct-write orientation of charge-transfer liquid crystals enables polarization-based coding and encryption

Madeline Van Winkle
Harper O. W. Wallace
Joseph J. Reczek
ResearchOpen Access18 Sept 2020
Scientific Reports

Volume: 10, P: 1-9
Brain-behaviour modes of covariation in healthy and clinically depressed young people

Agoston Mihalik
Fabio S. Ferreira
Janaina Mourão-Miranda
ResearchOpen Access08 Aug 2019
Scientific Reports

Volume: 9, P: 1-11
Differential susceptibility to CD95 (Apo-1/Fas) and MHC class II-induced apoptosis during murine dendritic cell development

A D McLellan
G Terbeck
E Kämpgen
Research28 Sept 2000
Cell Death & Differentiation

Volume: 7, P: 933-938
Author Correction: Corals regulate the distribution and abundance of Symbiodiniaceae and biomolecules in response to changing water depth and sea surface temperature

Mayandi Sivaguru
Lauren G. Todorov
Bruce W. Fouke
Amendments and CorrectionsOpen Access09 Nov 2023
Scientific Reports

Volume: 13, P: 1-2

Search

Development of a targeted BioPROTAC degrader selective for misfolded SOD1

Mutagenic effect of aromatic epoxy resins

Lactose Intolerance in Thailand

Bcl-2 overexpression blocks caspase activation and downstream apoptotic events instigated by photodynamic therapy

Photodynamic therapy induces caspase-3 activation in HL-60 cells

Toward a synthesis of Paleoamerican fluted point cultures in the Carolinas

Alarm Pheromone and Avoidance Conditioning in Goldfish, Carassius auratus

The Elephant Trench at Dewlish”Was it Dug?

Designation of Heavy Hydrogen

Fusion Of Uredospore Germ Tubes in Puccinia graminis

General the Hon. C. G. Bruce, C.B.

Do graded units of accretionary spheroids in the Barberton Greenstone Belt indicate Archaean deep water environment?

Thresholds for adding degraded tropical forest to the conservation estate

Serum Lipids and the Death of Spawning Pacific Salmon

Dimethyl Myleran Therapy Combined with Abdominal Aortic Occlusion

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors

Potentiation of the anti-tumour effects of Photofrin®-based photodynamic therapy by localized treatment with G-CSF

Nucleation and annihilation of skyrmions in Mn₂CoAl observed through the topological Hall effect

The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition

Heme oxygenase-1 protects tumor cells against photodynamic therapy-mediated cytotoxicity

The helper T lymphocyte precursor (HTLp) frequency does not predict outcome after HLA-identical sibling donor G-CSF-mobilised peripheral blood stem cell transplantation

Epithelial nuclear factor-κB signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes

Prediction of human population responses to toxic compounds by a collaborative competition

Distinct alterations in probabilistic reversal learning across at-risk mental state, first episode psychosis and persistent schizophrenia

Improved detection of clinically significant host-reactive antigens prior to HLA-identical sibling peripheral blood stem cell transplantation using a dendritic cell-based helper T-lymphocyte precursor assay

Serpina3n accelerates tissue repair in a diabetic mouse model of delayed wound healing

Lithium suppression of tau induces brain iron accumulation and neurodegeneration

Corals regulate the distribution and abundance of Symbiodiniaceae and biomolecules in response to changing water depth and sea surface temperature

Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes

Direct-write orientation of charge-transfer liquid crystals enables polarization-based coding and encryption

Brain-behaviour modes of covariation in healthy and clinically depressed young people

Differential susceptibility to CD95 (Apo-1/Fas) and MHC class II-induced apoptosis during murine dendritic cell development

Author Correction: Corals regulate the distribution and abundance of Symbiodiniaceae and biomolecules in response to changing water depth and sea surface temperature

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