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Showing 1–5 of 5 results
Advanced filters: Author: G. Romet-Lemonne Clear advanced filters

  • Fiolopodia are involved in cell migration and their attachment to the ECM is mediated by integrin receptors. Here the authors show that myosin X induced filipodia adhesion to fibronectin requires activity of myosin IIA at the filopodium base and formin at the tip to support force transmission through the actin core.

    • N. O. Alieva
    • A. K. Efremov
    • A. D. Bershadsky
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Cellular deformations are largely driven by contractile forces generated by myosin motors in the submembraneous actin cortex. Here we show that these forces are controlled not simply by cortical myosin levels, but rather by myosins spatial arrangement, specifically the extent of their overlap with cortical actin.

    • Binh An Truong Quang
    • Ruby Peters
    • Ewa K. Paluch
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Cortical tension is thought to be generated by myosin II, and little is known about the role of actin network properties. Chugh et al. demonstrate that actin cortex thickness, determined by actin filament length, influences cortical tension.

    • Priyamvada Chugh
    • Andrew G. Clark
    • Ewa K. Paluch
    Research
    Nature Cell Biology
    Volume: 19, P: 689-697

  • A new protein, Arpin, is identified that inhibits the Arp2/3 complex and controls cell migration by decreasing cell speed and the directional persistence of migration; this inhibitory circuit is under the control of the small GTPase Rac1, and Arpin depletion causes faster lamellipodia protrusion and increased cell migration.

    • Irene Dang
    • Roman Gorelik
    • Alexis Gautreau
    Research
    Nature
    Volume: 503, P: 281-284