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Showing 1–2 of 2 results
Advanced filters: Author: Gabriela Estepa Clear advanced filters

  • The desmoplastic stroma constitutes part of the microenvironment in pancreatic ductal adenocarcinoma. Here the authors show that Class I HDACs regulate the pro-desmoplastic and pro-tumorigenic transcriptional programs to support stromal activation and tumour progression.

    • Gaoyang Liang
    • Tae Gyu Oh
    • Ronald M. Evans
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • The epigenetic mechanisms underlying pancreatic ductal adenocarcinoma (PDAC) are not fully elucidated. Here, the authors reveal a druggable super-enhancer-mediated RNA-binding protein cascade that supports PDAC growth through enhanced mRNA translation.

    • Corina E. Antal
    • Tae Gyu Oh
    • Ronald M. Evans
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17