The selection of polyadenylation signals defines 3′UTR length. The authors find that MYC alters the expression of factors that repress strong polyadenylation signals at the distal end of genes, boosting usage of suboptimal, proximal polyadenylation signals and promoting the translation of cell cycle-related genes.
- Marco Pieraccioli
- Cinzia Caggiano
- Pamela Bielli