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Showing 1–2 of 2 results
Advanced filters: Author: Gabrielle A. Josling Clear advanced filters

  • The transcription factor PfAP2-G is a key determinant of sexual commitment in Plasmodium falciparum. Here, Josling et al. define the transcriptional regulatory network of PfAP2-G by identifying its DNA binding sites genome-wide, which vary depending on the route of sexual conversion and rely on interactions with the PfAP2-I transcription factor.

    • Gabrielle A. Josling
    • Timothy J. Russell
    • Manuel Llinás
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • For transmission from mammalian host to mosquito vector, blood-stage malaria parasites must convert from an asexual form to the sexual gametocyte through a process known as gametocytogenesis. In this Review, Josling and Llinás discuss recent studies that have begun to elucidate the molecular basis of this process, in particular the factors involved in commitment to gametocytogenesis.

    • Gabrielle A. Josling
    • Manuel Llinás
    Reviews
    Nature Reviews Microbiology
    Volume: 13, P: 573-587