Nature Search

Stimulus-driven cerebrospinal fluid dynamics is impaired in glaucoma patients

Ji Won Bang
Carlos Parra
Kevin C. Chan
ResearchOpen Access06 Jan 2026
npj Aging

Volume: 12, P: 1-11
Sensory integration abilities for balance in glaucoma, a preliminary study

Caitlin O’Connell
Mark Redfern
Rakié Cham
ResearchOpen Access04 Oct 2021
Scientific Reports

Volume: 11, P: 1-7
Evaluating Glaucoma Treatment Effect on Intraocular Pressure Reduction Using Propensity Score Weighted Regression

Mengfei Wu
Mengling Liu
Gadi Wollstein
ResearchOpen Access29 Oct 2019
Scientific Reports

Volume: 9, P: 1-6
Widespread brain reorganization perturbs visuomotor coordination in early glaucoma

Vivek Trivedi
Ji Won Bang
Kevin C. Chan
ResearchOpen Access02 Oct 2019
Scientific Reports

Volume: 9, P: 1-8
Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa

Bo Wang
Katie A. Lucy
Gadi Wollstein
ResearchOpen Access08 May 2018
Scientific Reports

Volume: 8, P: 1-7
Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes

Bo Wang
Katie A. Lucy
Gadi Wollstein
ResearchOpen Access30 Aug 2017
Scientific Reports

Volume: 7, P: 1-6
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities.

Puya Gharahkhani
Eric Jorgenson
Janey L. Wiggs
ResearchOpen Access24 Feb 2021
Nature Communications

Volume: 12, P: 1-16
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process

Glaucoma is the most common cause of irreversible blindness worldwide. Here, the authors carry out a large meta-analysis of genetic data from individuals of European and Asian ancestry and identify 10 new loci associated with vertical cup-disc ratio, a key factor in the clinical assessment of patients with glaucoma.

Henriët. Springelkamp
René Höhn
Christopher J. Hammond
ResearchOpen Access22 Sept 2014
Nature Communications

Volume: 5, P: 1-7
Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

Janey Wiggs, Jonathan Haines and colleagues identify three new susceptibility loci for primary open-angle glaucoma. The association signals map near genes implicated in ocular development (FOXC1), neurodegeneration (ATXN2) and mitochondrial function (TXNRD2).

Jessica N Cooke Bailey
Stephanie J Loomis
Janey L Wiggs
Research11 Jan 2016
Nature Genetics

Volume: 48, P: 189-194
Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

Elevated intraocular pressure (IOP) is a heritable risk factor for primary open angle glaucoma. Using forward mouse genetics, cell biology, pharmacology and human genetic data, the authors identify CACNA2D1 as an IOP risk gene that can be therapeutically targeted by the drug pregabalin in animal models.

Sumana R. Chintalapudi
Doaa Maria
Monica M. Jablonski
ResearchOpen Access24 Nov 2017
Nature Communications

Volume: 8, P: 1-12
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Reduced central corneal thickness (CCT) is observed in common eye diseases as well as in rare Mendelian disorders. Here, in a cross-ancestry GWAS, the authors identify 19 novel genetic loci associated with CCT, a subset of which is involved in rare corneal or connective tissue disorders.

Adriana I. Iglesias
Aniket Mishra
Stuart MacGregor
ResearchOpen Access14 May 2018
Nature Communications

Volume: 9, P: 1-11
GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients

Reduced GABA in the visual cortex of glaucoma patients is shown to be tightly linked to disruption of stimulus-specific neural representations.

Ji Won Bang
Carlos Parra
Kevin C. Chan
ResearchOpen Access29 Jun 2023
Communications Biology

Volume: 6, P: 1-11
Adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry

Rubinoff et al. develop an adaptive spectroscopic visible-light optical coherence tomography approach for the measurement of retinal oxygen saturation, a biomarker for several retinal diseases. Their approach, which is tested in ex vivo blood phantoms and healthy human volunteers, adaptively removes spectral contaminants to minimize error.

Ian Rubinoff
Roman V. Kuranov
Hao F. Zhang
ResearchOpen Access24 Apr 2023
Communications Medicine

Volume: 3, P: 1-11
Age-related Changes in Eye, Brain and Visuomotor Behavior in the DBA/2J Mouse Model of Chronic Glaucoma

Xiao-Ling Yang
Yolandi van der Merwe
Kevin C. Chan
ResearchOpen Access15 Mar 2018
Scientific Reports

Volume: 8, P: 1-11
Non-invasive MRI Assessments of Tissue Microstructures and Macromolecules in the Eye upon Biomechanical or Biochemical Modulation

Leon C. Ho
Ian A. Sigal
Kevin C. Chan
ResearchOpen Access26 Aug 2016
Scientific Reports

Volume: 6, P: 1-14
Retinal Structures and Visual Cortex Activity are Impaired Prior to Clinical Vision Loss in Glaucoma

Matthew C. Murphy
Ian P. Conner
Kevin C. Chan
ResearchOpen Access11 Aug 2016
Scientific Reports

Volume: 6, P: 1-11
Formalin Fixation and Cryosectioning Cause Only Minimal Changes in Shape or Size of Ocular Tissues

Huong Tran
Ning-Jiun Jan
Ian A. Sigal
ResearchOpen Access21 Sept 2017
Scientific Reports

Volume: 7, P: 1-11
Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis

Hugues Aschard
Jae H Kang
Louis R Pasquale
Research30 Aug 2017
European Journal of Human Genetics

Volume: 25, P: 1261-1267
Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Adriana I. Iglesias
Aniket Mishra
Stuart MacGregor
Amendments and CorrectionsOpen Access08 Jan 2019
Nature Communications

Volume: 10, P: 1-3
Mechanosensitive ion channel gene survey suggests potential roles in primary open angle glaucoma

Wendy W. Liu
Tyler G. Kinzy
Donald J. Zack
ResearchOpen Access23 Sept 2023
Scientific Reports

Volume: 13, P: 1-9
Multi-trait genome-wide association study identifies new loci associated with optic disc parameters

The International Glaucoma Genetics Consortium reports a genome-wide association study meta-analysis of optic disc parameters relevant to primary open-angle glaucoma. They identify two novel variants in PPP1R36-PLEKHG3 and SERPINE3 by multi-trait analysis in European-ancestry cohorts that were replicated in independent Asian cohorts.

Pieter W. M. Bonnemaijer
Elisabeth M. van Leeuwen
Cornelia M. van Duijn
ResearchOpen Access27 Nov 2019
Communications Biology

Volume: 2, P: 1-12
Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma

Puya Gharahkhani
Kathryn P. Burdon
Donald J. Zack
ResearchOpen Access15 Feb 2018
Scientific Reports

Volume: 8, P: 1-12

Search

Stimulus-driven cerebrospinal fluid dynamics is impaired in glaucoma patients

Sensory integration abilities for balance in glaucoma, a preliminary study

Evaluating Glaucoma Treatment Effect on Intraocular Pressure Reduction Using Propensity Score Weighted Regression

Widespread brain reorganization perturbs visuomotor coordination in early glaucoma

Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa

Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients

Adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry

Age-related Changes in Eye, Brain and Visuomotor Behavior in the DBA/2J Mouse Model of Chronic Glaucoma

Non-invasive MRI Assessments of Tissue Microstructures and Macromolecules in the Eye upon Biomechanical or Biochemical Modulation

Retinal Structures and Visual Cortex Activity are Impaired Prior to Clinical Vision Loss in Glaucoma

Formalin Fixation and Cryosectioning Cause Only Minimal Changes in Shape or Size of Ocular Tissues

Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis

Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Mechanosensitive ion channel gene survey suggests potential roles in primary open angle glaucoma

Multi-trait genome-wide association study identifies new loci associated with optic disc parameters

Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma

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