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Showing 1–14 of 14 results
Advanced filters: Author: Gael Cristofari Clear advanced filters

  • LINE-1 DNA elements self-duplicate, inserting the copy into new regions of the genome — a key process in chromosome evolution. Structures of the machinery that performs this process in humans are now reported.

    • Gael Cristofari
    News & Views
    Nature
    Volume: 626, P: 40-42

  • Using degron approaches, the authors show that cancer cells experiencing prolonged DNA methylation loss—without substantial DNA damage—undergo non-canonical senescence. This has important potential implications for cancer treatment.

    • Xiaoying Chen
    • Kosuke Yamaguchi
    • Pierre-Antoine Defossez
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22

  • Next-generation sequencing has facilitated the study of how transposable elements and retroviruses select their diverse genomic sites of integration, and revealed integration site preferences that range from specific nucleotide sequences to particular chromatin states. The authors review the various mechanisms of integration site selection in eukaryotes, as well as the molecular and cellular determinants that guide this process.

    • Tania Sultana
    • Alessia Zamborlini
    • Pascale Lesage
    Reviews
    Nature Reviews Genetics
    Volume: 18, P: 292-308

  • Here, the authors identify four novel regulators of the 2-cell-like state, and thus totipotency, via unbiased CRISPR knockout screens and Dazl re-expression as a readout. They show that these factors act upstream of DPPA2 and DUX, and independently of p53.

    • Nikhil Gupta
    • Lounis Yakhou
    • Pierre-Antoine Defossez
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 1105-1118

  • The human silencing hub (HUSH) complex, which includes TASOR, deposits repressive marks on HIV proviruses, resulting in gene repression. Here, Matkovic et al. show that TASOR interacts with RNA Polymerase II, predominantly under its elongating state, and RNA degradation proteins to repress HIV provirus expression.

    • Roy Matkovic
    • Marina Morel
    • Florence Margottin-Goguet
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Human Long INterspersed Element class 1 (LINE-1) elements are expressed and mobilized in many types of cancer, contributing to malignancy. Here the authors show that the tumor suppressor microRNA let-7 targets the LINE-1 mRNA and reduces LINE-1 mobilization.

    • Pablo Tristán-Ramos
    • Alejandro Rubio-Roldan
    • Sara R. Heras
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • EM analyses reveal the three-dimensional structure of human telomerase. Along with functional biochemistry data, the work reveals that telomerase is dimeric in its active form. Each of the two TERT subunits can bind telomeric DNA substrates, and both active sites are required for function.

    • Anselm Sauerwald
    • Sara Sandin
    • Daniela Rhodes
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 454-460

  • Mosquitoes tolerate long-lasting viral infections, which makes them efficient vectors for human viral diseases. Here, the authors show that the tolerance of Aedesmosquitoes to infection with dengue or chikungunya viruses depends on the production of viral-derived DNA by cellular reverse transcriptases.

    • Bertsy Goic
    • Kenneth A. Stapleford
    • Maria-Carla Saleh
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Retrotransposons are often thought of as 'selfish' genetic elements that replicate themselves without any obvious benefit to the host genome. Saleh and colleagues demonstrate that retrotransposons can be involved in generating silencing RNA species to regulate viral replication.

    • Bertsy Goic
    • Nicolas Vodovar
    • Maria-Carla Saleh
    Research
    Nature Immunology
    Volume: 14, P: 396-403

  • Computational tools to analyse RNA sequencing data often disregard or even misinterpret reads derived from transposable elements. This Review highlights the main challenges associated with the detection of transposable element expression, including mappability, sequence polymorphisms and transcript diversity, and discusses the experimental and computational strategies to overcome them.

    • Sophie Lanciano
    • Gael Cristofari
    Reviews
    Nature Reviews Genetics
    Volume: 21, P: 721-736