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Showing 1–6 of 6 results
Advanced filters: Author: Gaelle Le Friec Clear advanced filters

  • Recent studies have shown that complement activation is not confined to the serum but also occurs within cellular compartments. This has led to an emerging understanding that complement components can intersect diverse cellular metabolic and effector pathways. Here, the authors propose that the different locations of complement activation dictate its diverse functions.

    • Martin Kolev
    • Gaelle Le Friec
    • Claudia Kemper
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 811-820

  • Signaling via the complement factors C3a and C5a regulates effector T cell responses. Evidence now links the absence of local complement activation with a default pathway that leads to the polarization of Foxp3+ regulatory T cells.

    • Gaelle Le Friec
    • Jörg Köhl
    • Claudia Kemper
    News & Views
    Nature Immunology
    Volume: 14, P: 110-112

  • We demonstrate that the transmembrane protease TMPRSS2 is a receptor for coronavirus HKU1; it triggers HKU1-mediated cell–cell fusion and viral entry by binding to both HKU1A and HKU1B spikes.

    • Nell Saunders
    • Ignacio Fernandez
    • Olivier Schwartz
    Research
    Nature
    Volume: 624, P: 207-214

  • Complement, while serving to remove pathogens in the circulation, is also important for synergizing with inflammasomes to modulate CD4 T cell activation. Here the authors show that CD46, a complement receptor expressed only in humans, is essential for inducing optimal activation and effector functions of human CD8 T cells.

    • Giuseppina Arbore
    • Erin E. West
    • Claudia Kemper
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • The complement receptor CD46 and the Notch-Jagged system are important for the differentiation of helper T cells. Kemper and colleagues demonstrate that Jagged1 is a physiological ligand for CD46 and is critical for the generation of T helper type 1 cells in humans.

    • Gaëlle Le Friec
    • Devon Sheppard
    • Claudia Kemper
    Research
    Nature Immunology
    Volume: 13, P: 1213-1221