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Showing 1–7 of 7 results
Advanced filters: Author: Gal Bitan Clear advanced filters

  • Ion-mobility mass spectrometry has been used to identify and characterize the oligomeric assemblies of amyloid-β proteins under physiologically relevant conditions. Hexamers and dodecamers are formed only from Aβ42 proteins and the dodecamer is identified as a candidate for the primary toxic agent in the development of Alzheimer's disease.

    • Summer L. Bernstein
    • Nicholas F. Dupuis
    • Michael T. Bowers
    Research
    Nature Chemistry
    Volume: 1, P: 326-331

  • Effectiveness of one subcutaneous dose of MVA-BN, the smallpox and mpox vaccine, was estimated to be 86% in a cohort of vaccine-eligible males in Israel, supporting its use to curtail the outbreak of mpox virus.

    • Yael Wolff Sagy
    • Roy Zucker
    • Doron Netzer
    Research
    Nature Medicine
    Volume: 29, P: 748-752

  • In a phase 1/2 trial, the recombinant interleukin-1 receptor antagonist anankira was safe and associated with clinically meaningful improvements in neurobehavioral and quality-of-life outcomes in patients with Sanfilippo syndrome.

    • Lynda E. Polgreen
    • Agnes H. Chen
    • Julie B. Eisengart
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 2473-2479

  • CLR01 is a molecular tweezer that inhibits protein aggregation. Here the authors show that CLR01 protects dopaminergic neurons in vitro and in vivo in human neurons and in mouse models showing potential as a disease-modifying therapy for Parkinson’s disease.

    • Nora Bengoa-Vergniory
    • Emilie Faggiani
    • Richard Wade-Martins
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Li et al. design and synthesize fluorescently labeled molecular tweezers to explore their internalization, intracellular localization, and mechanism of endocytosis in brain cells including neurons and astrocytes. The authors find that MTs are internalized in neurons and astrocytes, at least partially through dynamin-dependent endocytosis, and concentrate rapidly in acidic compartments, primarily lysosomes.

    • Zizheng Li
    • Ibrar Siddique
    • Gal Bitan
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-15