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Showing 1–10 of 10 results
Advanced filters: Author: Galit Lahav Clear advanced filters

  • The complex web of regulation that surrounds the tumour suppressor p53 is well known, but few have considered the effect that this has on the dynamics of p53 itself. This forward-looking Perspective speculates on the insights that we might gain by examining the p53 dynamics in individual tumour cells.

    • Eric Batchelor
    • Alexander Loewer
    • Galit Lahav
    Reviews
    Nature Reviews Cancer
    Volume: 9, P: 371-377

  • p53 mediates the response to irradiation, however, tissues with similar levels of p53 have different radiation sensitivities. Here, the authors show that the in vivo p53 dynamics varies in these tissues after radiation, and the use of Mdm2 inhibitor to sustain p53 activity enhances radiosensitivity.

    • Jacob Stewart-Ornstein
    • Yoshiko Iwamoto
    • Galit Lahav
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • The origins of lineage correlations and heterogeneity in division and apoptosis times among single cells are incompletely understood. Here, a new lineage tracking data analysis approach reveals that circadian oscillations may underlie cell fate control and explain the observed correlation structures.

    • Shaon Chakrabarti
    • Andrew L. Paek
    • Franziska Michor
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • A mathematical method, known as ergodic rate analysis, has been developed and used to study the rates of molecular events from single time measurements of large populations of fixed cells; this new method is able to overcome some of the previous limitations with regards to studying cell-size control.

    • Ran Kafri
    • Jason Levy
    • Marc W. Kirschner
    Research
    Nature
    Volume: 494, P: 480-483

  • Lineage tracing by barcoding of individual cells using a lentivirus library shows that cycling and non-cycling drug-tolerant persister cells in cancer arise from different lineages with distinct transcriptional and metabolic programs.

    • Yaara Oren
    • Michael Tsabar
    • Aviv Regev
    Research
    Nature
    Volume: 596, P: 576-582

  • Following DNA damage, the transcription factor p53 determines whether cells undergo apoptosis or cell cycle arrest and DNA repair. To enable different cellular outcomes, p53 is regulated through its temporal expression dynamics and post-translational modification, and by interactions with chromatin, chromatin regulators and transcription factors.

    • Antonina Hafner
    • Martha L. Bulyk
    • Galit Lahav
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 20, P: 199-210